Personalized Multimodal Treatment for Adhesive Capsulitis: A Case Series on Regenerative Medicine and Noninvasive Therapies

Original Article | Vol 4 | Issue 2 |  July-December 2024 | page: 12-14 | Napoliane Costa Santos, André Vinicius Saueressig Kruel, Alex Pontes de Macedo, Fabio Ramos Costa, Luyddy Pires, Maria Laura Schiefelbein, Palmerindo Antônio Tavares de Mendonça Néto, Renata Takeyama de Oliveira, Daiane Agostini, Jose Fábio Lana

DOI: https://doi.org/10.13107/jrs.2024.v04.i02.145


Author: Napoliane Costa Santos [1], André Vinicius Saueressig Kruel [2], Alex Pontes de Macedo [1], Fabio Ramos Costa [3], Luyddy Pires [1], Maria Laura Schiefelbein [4], Palmerindo Antônio Tavares de Mendonça Néto [5], Renata Takeyama de Oliveira [1], Daiane Agostini [2], Jose Fábio Lana [1]

[1] Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil,
[2] Proregen Clínica Médica, Bento Gonçalves, Rio Grande do Sul, Brasil.
[3] TRATE – Traumatologia Esportiva, Salvador, Brazil,
[4] Departamento de Ortopedia, TRATE, Traumatologia Esportiva, Salvador, BA, Brazil, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil,
[5] Instituto Regenera Dor, Juazeiro do Norte, Ceará, Brazil.

Address of Correspondence
Dr. André Kruel
Proregen Clínica Médica, Bento Gonçalves, Rio Grande do Sul, Brasil.
E-mail: kruel.andre@gmail.com


Abstract

Introduction: Adhesive capsulitis causes chronic shoulder pain and restricted range of motion (ROM). Conventional treatments often offer limited relief, prompting the need for innovative approaches, such as high-intensity pulsed electromagnetic field (PEMF) therapy, shockwave therapy, and orthobiologic injections.

Objective: To evaluate the efficacy of a multimodal approach combining shockwave therapy, high-intensity PEMF therapy, orthobiologic injections, and complementary therapies in improving pain and shoulder function in patients with adhesive capsulitis.

Methods: This retrospective case series included five patients treated in Indaiatuba, São Paulo, Brazil, between May 2023 and October 2024. Individualized multimodal protocols were performed. Pain and ROM were assessed pre- and post-treatment.

Discussion: All patients showed significant improvements in pain and ROM after treatment. High-intensity PEMF therapy, shockwave therapy, and orthobiologics enhanced tissue regeneration, supported by complementary therapies. Personalized protocols optimized outcomes, with synergistic effects observed between treatments.

Conclusion: A multimodal, personalized approach effectively reduced pain and improved function in adhesive capsulitis patients. This strategy shows promise, especially for those unresponsive to conventional treatments, warranting further research.

Keywords: Adhesive capsulitis, High intensity pulsed electromagnetic field therapy, Orthobiologics, Regenerative medicine, Shockwave therapy


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How to Cite this article: Santos NC, Saueressig Kruel AV, de Macedo AP, Costa FR, Pires L, Schiefelbein ML, de Mendonça Néto PAT, de Oliveira RT, Agostini D, Fábio Lana J | Personalized Multimodal Treatment for Adhesive Capsulitis: A Case Series on Regenerative Medicine and Noninvasive Therapies. | Journal of Regenerative Science | July-December 2024; 4(2): 12-17.

 

 


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Extracorporeal Shock Waves in Metabolic Inflammation

Review Article | Vol 4 | Issue 2 |  July-December 2024 | page: 18-25 | Cláudio Lopes Simplício, Izair Jefthe Rodrigues, Guilherme Antônio Moreira De Barros

DOI: https://doi.org/10.13107/jrs.2024.v04.i02.147


Author: Cláudio Lopes Simplício [1], Izair Jefthe Rodrigues [2], Guilherme Antônio Moreira De Barros [3]

[1] RJ Brazil Ortofisio Clinic – Instdor Clinic, São Paulo State University (UNESP), Botucatu, Brazil,
[2] Department of Neurosurgery, Regen® Institute of Reparative Medicine, Valinhos, São Paulo, Brazil.
[3] Antalgic Therapy and Palliative Care Department, Faculdade de Medicina de Botucatu, UNESP-SP, Botucatu, Brazil

Address of Correspondence
Dr. Cláudio Lopes Simplício,

São Paulo State University (UNESP), Botucatu, Brazil.

E-mail:c.simplicio@unesp.br


Abstract

Adhesive The presentation of this paper provides a comprehensive overview of the challenges associated with metabolic syndrome in clinical practice, while highlighting the innovative role of extracorporeal shock waves as a therapeutic tool to manage metabolic inflammation. A multidisciplinary approach is emphasized, suggesting that collaboration among different areas of expertise is essential to improve patient health outcomes.
Keywords: Metabolic inflammation, Oxidative stress, Extracorporeal shock waves


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How to Cite this article: Simplício CL, Rodrigues IJ, De Barros GA. Extracorporeal Shock Waves in Metabolic Inflammation. | Journal of Regenerative Science | July-December 2024; 4(2): 18-25.

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Extracorporeal Shock Waves and Ultrasound: A Combined Approach in the Treatment of Musculoskeletal Injuries

Original Article | Vol 4 | Issue 2 |  July-December 2024 | page: 26-31 | Cláudio Lopes Simplício, Everaldo Gregio-Junior, Guilherme Antônio Moreira de Barros, Izair Jefthe Rodrigues

DOI: https://doi.org/10.13107/jrs.2024.v04.i02.149


Author: Cláudio Lopes Simplício [1], Everaldo Gregio-Junior [2], Guilherme Antônio Moreira de Barros [3], Izair Jefthe Rodrigues [4]

[1] Orthopedics – Physiatrist – Antalgic Therapy, RJ Brazil Ortofisio Clinic – Instdor Clinic- São Paulo State, University (UNESP) Botucatu – São Paulo, Brazil,
[2] Department of Medical Imaging, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil; Professor of the Ultrasonography course at Cetrus School, São Paulo, Brazil,
[3] Department of Antalgic Therapy and Palliative Care, Antalgic Therapy and Palliative Care, Faculdade de Medicina de Botucatu, UNESP, São Paulo, Brazil,
[4] Department of Neurosurgery, Regen® Institute of Reparative Medicine, Valinhos, São Paulo, Brazil

Address of Correspondence
Dr. Cláudio Lopes Simplício,

Orthopedics – Physiatrist – Antalgic Therapy, RJ Brazil Ortofisio Clinic – Instdor Clinic- São Paulo State, University (UNESP) Botucatu – São Paulo, Brazil.

Email: c.simplicio@unesp.br


Abstract

The combination of extracorporeal shock wave therapy (ESWT) and ultrasound (US) emerges as an innovative and effective approach in the treatment of musculoskeletal injuries. This integration provides significant benefits in both diagnosis and treatment, resulting in better clinical outcomes and faster recovery for patients. US stands out as a non-invasive diagnostic tool that offers real-time imaging, and is widely used in the assessment of various musculoskeletal conditions, including injuries to the shoulder, elbow, wrist, knee, and ankle.
ESWT is an effective method that has expanded to treat a variety of musculoskeletal pathologies through the application of acoustic waves. The interaction between US and shock waves is crucial in ensuring precision in interventions, allowing for more targeted and effective treatment.
In addition to enhancing the accuracy of injections and therapeutic interventions, US also plays a critical role in monitoring clinical progress and the early detection of complications. Studies show that the combination of these approaches results in significant pain relief and improved functionality for patients. Therefore, the integrated use of US and shock wave therapy represents a valuable strategy in the management of musculoskeletal injuries, broadening its application in clinical practices.
Keywords: Ultrasound, Musculoskeletal injuries, Extracorporeal shock waves


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30. Raeissadat, S. A., Rayegani, S. M., Faghihi Langroudi, T., & Khoiniha, M. (2017). Comparing the accuracy and efficacy of ultrasound-guided versus blind injections of steroid in the glenohumeral joint in patients with shoulder adhesive capsulitis. Clinical Rheumatology, 36(4), 933-940. https://doi.org/10.1007/s10067-016-3393-8
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32. Paoletta, M., Moretti, A., Liguori, S., Snichelotto, F., Menditto, I., Toro, G., Gimigliano, F., & Iolascon, G. (2021). Ultrasound imaging in sport-related muscle injuries: Pitfalls and opportunities. Medicina, 57(10), 1040. https://doi.org/10.3390/medicina57101040
33. Saha, P., Smith, M., & Hasan, K. (2023). Accuracy of Intraarticular Injections: Blind vs. Image Guided Techniques,Review of Literature. Journal of Functional Morphology and Kinesiology, 8, 93. https://doi.org/10.3390/jfmk8030093
34. Shin, Y., Yang, J., Lee, Y. H., & Kim, S. (2021). Artificial intelligence in musculoskeletal ultrasound imaging. Ultrasonography, 40(1), 30-44. https://doi.org/10.14366/usg.20080
35. Fodor, D., Rodriguez-Garcia, S. C., Cantisani, V., Hammer, H. B., Hartung, W., Klauser, A., Martinoli, C., Terslev, L., Alfageme, F., Bong, D., Bueno, A., Collado, P., D’Agostino, M. A., de la Fuente, J., Iohom, G., Kessler, J., Lenghel, M., Malattia, C., Mandl, P., Mendoza-Cembranos, D., Micu, M., Möller, I., Najm, A., Özçakar, L., Picasso, R., Plagou, A., Sala-Blanch, X., Sconfienza, L. M., Serban, O., Simoni, P., Sudoł-Szopińska, I., Tesch, C., Todorov, P., Uson, J., Vlad, V., Zaottini, F., Bilous, D., Gutiu, R., Pelea, M., Marian, A., & Naredo, E. (2021). The EFSUMB Guidelines and Recommendations for Musculoskeletal Ultrasound – Part I: Extraarticular Pathologies. Die EFSUMB-Leitlinien und -Empfehlungen für den muskuloskelettalen Ultraschall. Teil I: Extraartikuläre Pathologien. Supplementary material available at: https://doi.org/10.1055/a-1562-1455
36. Akçin, A. İ., Eyvaz, N., Dündar, Ü., Toktaş, H., Yeşil, H., Eroğlu, S., & Adar, S. (2025). The clinical efficacy of extracorporeal shock wave therapy combined with platelet rich plasma and exercise for lateral epicondylitis: Prospective randomized sham-controlled ultrasonographic study. Archives of Physical Medicine and Rehabilitation. https://doi.org/10.1016/j.apmr.2025.01.420


How to Cite this article: Simplício CL, Junior EG, Barros GAMD, Rodrigues IJ | Extracorporeal Shock Waves and Ultrasound: A Combined Approach in the Treatment of Musculoskeletal Injuries. | Journal of Regenerative Science | July-December 2024; 4(2): 00-00.

 


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Extracorporeal Shockwave Therapy in the Treatment of Adhesive Capsulitis of the Shoulder: A Novel Approach-CapsuWave

Original Article | Vol 4 | Issue 2 |  July-December 2024 | page: 32-39 | Cláudio Lopes Simplício, Daiane Agostini, André V. S. Kruel, Guilherme Antônio Moreira de Barros, Izair Jefthe Rodrigues

DOI: https://doi.org/10.13107/jrs.2024.v04.i02.151


Author: Cláudio Lopes Simplício, Daiane Agostini, André V. S. Kruel, Guilherme Antônio Moreira de Barros, Izair Jefthe Rodrigues

[1] RJ Brazil Ortofisio Clinic-Instdor Clinic-São Paulo State, Universidade Estadual Paulista, Botucatu–São Paulo, Brazil,
[2] Proregen Clinic-Bento Gonçalves, State of Rio Grande do Sul, Brazil,
[3] Proregen Clinic, Bento Gonçalves-State of Rio Grande do Sul, Brazil,
[4] Antalgic Therapy and Palliative Care, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo, Brazil,
[5] Regen® Institute of Reparative Medicine, São Paulo, Brazil.

Address of Correspondence
Cláudio Lopes Simplício,
RJ Brazil Ortofisio Clinic-Instdor Clinic-São Paulo State, Universidade Estadual Paulista, Botucatu–São Paulo, Brazil.
E-mail: c.simplicio@unesp.br


Abstract

Adhesive capsulitis, commonly known as frozen shoulder, is a musculoskeletal condition characterized by intense pain and progressive limitation of mobility in the glenohumeral joint, often associated with diseases such as diabetes and autoimmune conditions. Its etiology remains incompletely understood but involves inflammatory and fibrotic factors that lead to adhesions of the articular capsule. The clinical presentation is divided into three phases: Inflammatory, frozen, and resolution, each varying in duration and symptom intensity. Extracorporeal shockwave therapy (ESWT) has emerged as a non-invasive treatment approach for this condition, showing positive results in improving range of motion and reducing pain. ESWT works by modulating the inflammatory response and promoting tissue regeneration, as evidenced by studies demonstrating its beneficial effects, especially when combined with other therapies. A detailed case study of a 58-year-old patient with a trauma history indicating adhesive capsulitis is presented, highlighting the symptoms and limitations encountered. Treatment included shockwave applications, following the CapsuWave technique, which optimizes treatment administration. Results suggest that ESWT offers a more accelerated functional recovery compared to other therapies, such as corticosteroid injections. Continued investigation into the pathophysiology of adhesive capsulitis and the efficacy of shockwave therapy is crucial for developing more effective treatment options. A multidisciplinary approach, integrating diverse areas of medicine, is essential for the proper management of this complex condition, aiming not only for pain reduction but also for improving the patients’ quality of life.
Keywords: Adhesive capsulitis, Shoulder pain, Extracorporeal shockwave therapy


References:

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24. Chang TH, Lin WR, Tsai WK, Chiang PK, Chen M, Tseng JS, et al. Comparison of ultrasound-assisted and pure fluoroscopy-guided extracorporeal shockwave lithotripsy for renal stones. BMC Urol 2020;20:183.
25. Jakobeit C, Winiarski B, Jakobeit S, Welp L, Spelsberg G. Ultrasound-guided, high-energy extracorporeal – shock-wave treatment of symptomatic calcareous tendinopathy of the shoulder. ANZ J Surg 2002;72:496-500.
26. Bechay J, Lawrence C, Namdari S. Calcific tendinopathy of the rotator cuff: A review of operative versus nonoperative management. Phys Sportsmed 2020;78:241-6.
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28. Anwar N, Li S, Long L, Zhou L, Fan M, Zhou Y, et al. Combined effectiveness of extracorporeal radial shockwave therapy and ultrasound-guided trigger point injection of lidocaine in upper trapezius myofascial pain syndrome. Am J Transl Res 2022;14:182-96.
29. Fang, W. H., Chen, X. T., & Vangsness Jr, C. T. (2021). Ultrasound-Guided Knee Injections Are More Accurate Than Blind Injections: A Systematic Review of Randomized Controlled Trials. Arthroscopy, Sports Medicine, and Rehabilitation, 3(4), e1177-e1184. https://doi.org/10.1016/j.asmr.2021.01.028.
30. Raeissadat, S. A., Rayegani, S. M., Faghihi Langroudi, T., & Khoiniha, M. (2017). Comparing the accuracy and efficacy of ultrasound-guided versus blind injections of steroid in the glenohumeral joint in patients with shoulder adhesive capsulitis. Clinical Rheumatology, 36(4), 933-940. https://doi.org/10.1007/s10067-016-3393-8.
31. Lee, H.-J., Lim, K.-B., Kim, D.-Y., & Lee, K.-T. (2009). Randomized controlled trial for efficacy of intra-articular injection for adhesive capsulitis: ultrasonography-guided versus blind technique. Archives of Physical Medicine and Rehabilitation, 90(12), 1997-2002. https://doi.org/10.1016/j.apmr.2009.07.025.
32. Paoletta, M., Moretti, A., Liguori, S., Snichelotto, F., Menditto, I., Toro, G., Gimigliano, F., & Iolascon, G. (2021). Ultrasound imaging in sport-related muscle injuries: Pitfalls and opportunities. Medicina, 57(10), 1040. https://doi.org/10.3390/medicina57101040.
33. Saha, P., Smith, M., & Hasan, K. (2023). Accuracy of Intraarticular Injections: Blind vs. Image Guided Techniques,Review of Literature. Journal of Functional Morphology and Kinesiology, 8, 93. https://doi.org/10.3390/jfmk8030093.
34. Shin, Y., Yang, J., Lee, Y. H., & Kim, S. (2021). Artificial intelligence in musculoskeletal ultrasound imaging. Ultrasonography, 40(1), 30-44. https://doi.org/10.14366/usg.20080.
35. Fodor, D., Rodriguez-Garcia, S. C., Cantisani, V., Hammer, H. B., Hartung, W., Klauser, A., Martinoli, C., Terslev, L., Alfageme, F., Bong, D., Bueno, A., Collado, P., D’Agostino, M. A., de la Fuente, J., Iohom, G., Kessler, J., Lenghel, M., Malattia, C., Mandl, P., Mendoza-Cembranos, D., Micu, M., Möller, I., Najm, A., Özçakar, L., Picasso, R., Plagou, A., Sala-Blanch, X., Sconfienza, L. M., Serban, O., Simoni, P., Sudoł-Szopińska, I., Tesch, C., Todorov, P., Uson, J., Vlad, V., Zaottini, F., Bilous, D., Gutiu, R., Pelea, M., Marian, A., & Naredo, E. (2021). The EFSUMB Guidelines and Recommendations for Musculoskeletal Ultrasound – Part I: Extraarticular Pathologies. Die EFSUMB-Leitlinien und -Empfehlungen für den muskuloskelettalen Ultraschall. Teil I: Extraartikuläre Pathologien. Supplementary material available at: https://doi.org/10.1055/a-1562-1455.
36. Akçin, A. İ., Eyvaz, N., Dündar, Ü., Toktaş, H., Yeşil, H., Eroğlu, S., & Adar, S. (2025). The clinical efficacy of extracorporeal shock wave therapy combined with platelet rich plasma and exercise for lateral epicondylitis: Prospective randomized sham-controlled ultrasonographic study. Archives of Physical Medicine and Rehabilitation. https://doi.org/10.1016/j.apmr.2025.01.420.


How to Cite this article: Simplício CL, Agostini D, Kruel AVS, de Barros GAM, Rodrigues IJ. Extracorporeal Shockwave Therapy in the Treatment of Adhesive Capsulitis of the Shoulder: A Novel Approach-CapsuWave. | Journal of Regenerative Science | July-December 2024; 4(2): 32-39.

 

 


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The power of case reports

Editorial | Vol 4 | Issue 1 |  January-June 2024 | page: 01-02 | Daniel Moya

DOI: https://doi.org/10.13107/jrs.2024.v04.i01.117


Author: Daniel Moya [1]

[1] Department of Orthopaedics. Buenos Aires British Hospital, Argentina.


Address of Correspondence
Dr. Daniel Moya,
Department of Orthopaedics. Buenos Aires British Hospital, Argentina.
E-mail: drdanielmoya@yahoo.com.ar


Editorial:

Medical education has currently a variety of tools as never before in the history of mankind. Options include everything from telepresence to virtual reality. However, interaction with patients remains, as in the past, an unsurpassed source of learning. Health-care practice provides learning about the way different pathologies manifest, their clinical course, and the response to different treatments.

A simple way to share that experience is through case reporting. A case report consists of a detailed description of significant clinical information of a case or a small group of patients, presenting pathologies not previously described, new therapeutic methodologies, or cases with an unusual response to treatment.

This type of study has often been underestimated because it is a category of publication with a low level of evidence [1-4] and does not have a high citation rate [1, 2, 4, 5]. These causes have led to case reports being a small segment of health publications [4].

However, these studies can provide important information [1-9]. Case reports can be the basis of future large-scale clinical studies [6], can reveal facts that often go unnoticed in large series of patients [3], and be the starting point for the development of new treatments [3]. They can demonstrate results in one or a few cases with therapeutic methods previously tested in animal experiments [4].

Case reports have made it possible to detect severe adverse effects [3, 4]. Nayak described that the teratogenic effect of thalidomide was identified through a case report of phocomelia [3].

We must also be aware that the publication of a case report is often the first step of a young colleague in the world of publications. That is why it should be encouraged. The publication of case reports allows even those who have less economic or institutional support for their academic activity to transmit their experience. It is a way to democratize scientific exchange and not depend only on supposed elites that end up transforming clinical research production groups into small aristocracies that generate only a one-way exchange.

Writing a case report has been described not only as an academic procedure but also as an art [8].

There is useful information in the literature about how to write this type of manuscripts [3, 4, 6, 8, 10]. Cases must be original and transmit information that has an impact on clinical practice. They must be structured like the rest of the publications, provide a complete and correct description of the case, and have solid bibliographic support.

Starting in this volume we will include case reports. On this occasion, they come from different colleagues from Ibero America. We also incorporated a new section that consists of critical reading of scientific publications related to regenerative medicine. Contributions, proposals, and criticisms will be welcome.


References

  1. Shyam A, Shetty G. Resurrection of the case report! J Orthop Case Rep 2011;1:1-2.
  2. Shyam A, Editor-Journal of Orthopaedic Case Reports. Case reports and case series: Expanding the scope of journal of orthopaedic case reports. J Orthop Case Rep 2016;6:1-2.
  3. Nayak BK. The significance of case reports in biomedical publication. Indian J Ophthalmol 2010;58:363-4.
  4. Pierson DJ. How to read a case report (or teaching case of the month). Respir Care 2009;54:1372-8.
  5. Hess DR. What is evidence-based medicine and why should I care? Respir Care 2004;49:730-41.
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How to Cite this article: Moya D | The Power of Case Reports. | Journal of Regenerative Science | Jan-Jun 2024; 4(1): 01-02.


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Extracorporeal Shock Wave Therapy in Calcifying Tendonitis of the Shoulder. Case Report

Case Report | Vol 4 | Issue 1 |  January-June 2024 | page: 03-05 | Oyama Arruda Frei Caneca Júnior

DOI: https://doi.org/10.13107/jrs.2024.v04.i01.119

 

Author: Oyama Arruda Frei Caneca Júnior [1]

[1] GOT – Orthopedics and Traumatology Group, Recife, Brazil.

Address of Correspondence
Oyama Arruda Frei Caneca Júnior,

GOT – Orthopedics and Traumatology Group, Recife, Brazil.

E-mail: oyama.arruda@gmail.com


Abstract

Calcific tendonitis in the shoulder is very common. Patients who do not improve with physical therapy treatment may benefit from shockwave treatment before an invasive procedure is indicated. The focused shockwave treatment has a high degree of recommendation in calcific tendonitis of the shoulder, according to several studies with a high level of evidence. This report shows a 58-year-old female patient with calcific tendonitis of the shoulder with pain for more than 6 months without response to medication and rehabilitation treatment. Four sessions of 3000 pulses were performed with a focused shockwave piezoelectric device, with a maximum level of energy of 0.4 mj/mm2. Pain remission and calcification resorption were verified 3 months after the last application. Extracorporeal Shockwave Treatment is a safe and effective alternative for calcific tendonitis of the shoulder.
Keywords: ESWT, calcific tendinopathy, shoulder


References:

1. Chianca V, Albano D, Messina C, Midiri F, Mauri G, Aliprandi A, et al. Rotator cuff calcific tendinopathy: From diagnosis to treatment. Acta Biomed 2018;89:186-96.
2. Moreira G. Tratado de Dor Musculo Esquelética. 2ª ed. Cap. 18. Dor no Ombro. São Paulo: Ed. Alef; 2022.
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7. Moya D, Ramón S, Schaden W, Wang CJ, Guiloff L, Cheng JH. The role of extracorporeal shockwave treatment in musculoskeletal disorders. J Bone Joint Surg Am 2018;100:251-63.
8. Moya D, Ramón S, Guiloff L, Gerdesmeyer L. Current knowledge on evidence-based shockwave treatments for shoulder pathology. Int J Surg 2015;24:171-8.


How to Cite this article: Caneca OAF Jr. Extracorporeal Shock Wave Therapy in Calcifying Tendonitis of the Shoulder. Case Report. Journal of Regenerative Science 2024;January-June;4(1):03-05

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Focused Shock Waves in Delayed Union and No-union after Intramedullary Nailing in Lower Limbs

Case Report | Vol 4 | Issue 1 |  January-June 2024 | page: 06-08 | Josep Pous

DOI: https://doi.org/10.13107/jrs.2024.v04.i01.121

 

Author: Josep Pous [1]

[1] Orthopaedic Surgeon and Medical Director of CEMATEC, Barcelona, España.

Address of Correspondence
Dr. Josep Pous,
Orthopaedic Surgeon and Medical Director of CEMATEC, Barcelona, España.
E-mail: jpous@cematec.org


Abstract

Shock waves have changed medical therapy substantially. Accounting for the epidemiology of the treated diseases, this therapeutic tool may equal or even surpass the impact of extracorporeal shock wave lithotripsy. Lower limb fractures after intramedullary nailing generally heal without problems when there are good local conditions and no associated pathologies, but sometimes if the biomechanical or biological variables are not ideal, they can lead to a delay in healing or develop a non-union. Extracorporeal shock waves therapy is a treatment option in delayed union and no-union after intramedullary nailing in lower limbs cases in which there is mechanical stability of the fracture focus, as they can allow healing without the need for new surgeries.
Keywords: Extracorporeal shockwave therapy, Shock waves, Non-union, Delayed union


References:

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11. Wang CJ, Huang KE, Sun YC, Yang YJ, Ko JY, Weng LH, et al. VEGF modulates angiogenesis and osteogenesis in shockwave-promoted fracture healing in rabbits. J Surg Res 2011;171:114-9.
12. Li B, Wang R, Huang X, Ou Y, Jia Z, Lin S, et al. Extracorporeal shock wave therapy promotes osteogenic differentiation in a rabbit osteoporosis model. Front Endocrinol (Lausanne) 2021;12:627718.
13. Haupt G. Use of extracorporeal shock waves in the treatment of pseudarthrosis, tendinopathy and other orthopedic diseases. J Urol 1997;158:4-11.
14. Alkhawashki HM. Shock wave therapy of fracture nonunion. Injury 2015;46:2248-52.
15. Willems A, Van der Jagt OP, Meuffels DE. Extracorporeal shock wave treatment for delayed union and nonunion fractures: A systematic review. J Orthop Trauma 2019;33:97-103.
16. Sansone V, Ravier D, Pascale V, Applefield R, Del Fabbro M, Martinelli N. Extracorporeal shockwave therapy in the treatment of nonunion in long bones: A systematic review and meta-analysis. J Clin Med 2022;11:1977.
17. Wang CJ, Chen HS, Chen CE, Yang KD. Treatment of nonunions of long bone fractures with shock waves. Clin Orthop Relat Res 2001;387:95-101.
18. Cacchio A, Giordano L, Colafarina O, Rompe JD, Tavernese E, Ioppolo F, et al. Extracorporeal shock-wave therapy compared with surgery for hypertrophic long-bone nonunions. J Bone Joint Surg Am 2009;91:2589-97. Erratum in: J Bone Joint Surg Am 2010;92:1241.
19. Furia JP, Juliano PJ, Wade AM, Schaden W, Mittermayr R. Shock wave therapy compared with intramedullary screw fixation for nonunion of proximal fifth metatarsal metaphyseal-diaphyseal fractures. J Bone Joint Surg Am 2010;92:846-54.
20. Notarnicola A, Moretti L, Tafuri S, Gigliotti S, Russo S, Musci L, et al. Extracorporeal shockwaves versus surgery in the treatment of pseudoarthrosis of the carpal scaphoid. Ultrasound Med Biol 2010;36:1306-13.
21. Schaden W, Mittermayr R, Haffner N, Smolen D, Gerdesmeyer L, Wang CJ. Extracorporeal shockwave therapy (ESWT)–first choice treatment of fracture non-unions? Int J Surg 2015;24:179-83.
22. Haffner N, Antonic V, Smolen D, Slezak P, Schaden W, Mittermayr R, et al. Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy. Injury 2016;47:1506-13.
23. Sandoval C, Valenzuela A, Rojas C, Brañes M, Guiloff L. Extracorporeal shockwave therapy for atrophic and oligotrophic nonunion of tibia and femur in high energy trauma patients. Case series. Int J Surg 2017;9:36-40.


How to Cite this article: Pous J. Focused Shock Waves in Delayed Union and No-union after Intramedullary Nailing in Lower Limbs. Journal of Regenerative Science 2024;January-June;4(1):06-08

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Treatment with Shockwave Therapy in a Patient with Joint Hypermobility and Temporomandibular Dysfunction

Case Report | Vol 4 | Issue 1 |  January-June 2024 | page: 09-15| Claudio Lopes Simplicio, Angélle Aragonez Essado Jácomo, Guilherme Antonio Moreira de Barros

DOI: https://doi.org/10.13107/jrs.2024.v04.i01.123

Author: Claudio Lopes Simplicio [1], Angélle Aragonez Essado Jácomo [2], Guilherme Antonio Moreira de Barros [3]

[1] Orthopedics – Physiatrist – Antalgic Therapy, RJ Brazil Ortofisio Clinic – Instdor Clinic, Sao Paulo State University (UNESP), Botucatu – SP Brazil,
[2] Physiatrist – Pain Doctor, DF, Brazil.
[3] Antalgic Therapy and Palliative Care, Faculdade de Medicina de Botucatu, UNESP-SP, Brazil.

Address of Correspondence
Dr. Cláudio Simplicio,
Orthopedics – Physiatrist – Antalgic Therapy,RJ Brazil, Ortofisio Clinic – Instdor Clinic, Sao Paulo State University (UNESP), Botucatu – SP Brazil.
E-mail: drsimplicio@terra.com.br


Abstract

The text addresses the relationship between joint hypermobility (JH), Ehlers-Danlos Syndrome (EDS), and temporomandibular dysfunction (TMD) in patients, discussing the complexity, and comorbidities associated with these conditions. A clinical case is presented, along with the treatment, including focused shockwave therapy as a non-invasive therapeutic approach. The effectiveness of shockwave therapy is discussed in relation to pain relief and musculoskeletal system regeneration, based on studies and scientific evidence.
However, despite the potential benefits, further research is still needed to fully understand the effects of these therapies in patients with specific conditions, such as JHjoint hypermobility and ehlers-danlos syndrome (EDS. The safety and efficacy of shockwave therapy are also discussed, emphasizing the importance of following rigorous protocols to avoid complications.
This summary highlights the relevance of shockwave therapy in the treatment of TMD and other musculoskeletal conditions, providing a comprehensive view of therapeutic approaches and clinical considerations involved.
Keywords: Joint Hypermobility, Ehlers-Danlos Syndrome, Temporomandibular Joint Dysfunction Syndrome, Extracorporeal Shockwave Therapy


References:


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How to Cite this article:  Simplicio CL, Jácomo AAE, de Barros GAM. Treatment with Shockwave Therapy in a Patient with Joint Hypermobility and Temporomandibular Dysfunction. Journal of Regenerative Science | 2024; January-June;4(1):09-15.

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A Diagnostic Mistake, Treated with Shock Waves: Dabska Tumor

Case Report | Vol 4 | Issue 1 |  January-June 2024 | page: 16-19| Paul Germán Terán Vela, Felipe Sebastián Criollo Palacios, Estefanía Anabel Lozada Tobar, Luis Eduardo Guzmán Freire, Eloísa Abigael Nájera García

DOI: https://doi.org/10.13107/jrs.2024.v04.i01.125

Author: Paul Germán Terán Vela [1], Felipe Sebastián Criollo Palacios [2], Estefanía Anabel Lozada Tobar [1], Luis Eduardo Guzmán Freire [3], Eloísa Abigael Nájera García [2]

 

[1] Orthopaedic Surgeon, Orthopedic Specialties Center, Quito-Ecuador,
[2] NGC Diagnóstica, Orthopedic Oncology, Quito-Ecuador,
[3] Physician, Orthopedic Specialties Center, Quito-Ecuador.

Address of Correspondence
Dr. Paul Germán Terán Vela,
Orthopaedic Surgeon, Orthopedic Specialties Center, Quito-Ecuador.
E-mail: paulteranmd@gmail.com


Abstract

Papillary intralymphatic angioendothelioma (PILA) or Dabska tumor (DT) is a low-grade angiosarcoma. This vascular tumor usually has a higher incidence during childhood and occurs the most in the extremities and trunk. DT is locally aggressive, and no high metastatic potential is reported. We present a case of a 34-year-old female patient, treated with extracorporeal shock wave therapy (ESWT) for a misdiagnosis of left patellar tendinopathy. Due to the persistence and intensification of her symptoms, she is re-evaluated by Orthopedic Specialists. In magnetic resonance imaging studies, a mass was identified in the left external femoral condyle measuring approximately 10 mm with significant diffuse bone edema. Surgical resection was performed, and a PILA was identified by immunohistochemistry. In this case report, the complications of the use of focused ESWT and the histopathological characteristics of DT are discussed.
Keywords: Dabska tumor, Intralymphatic papillary angioendothelioma, Focused shock waves, Complications


References:


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How to Cite this article: Vela PGT, Palacios FSC, Tobar EAL, Freire LEG, García EAN. A Diagnostic Mistake, Treated with Shock Waves: Dabska Tumor. Journal of Regenerative Science 2024;January-June;4(1):16-19.

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Regeneration of the Patellar Tendon with Radial Pressure Waves in a Sharp Injury: A Case Report

Case Report | Vol 4 | Issue 1 |  January-June 2024 | page: 20-23 | A A Flores Salinas, G C Reyes Cordero, L B García Rodriguez, L C Villa Olivares

DOI: https://doi.org/10.13107/jrs.2024.v04.i01.127

Author: A A Flores Salinas [1], G C Reyes Cordero [2], L B García Rodriguez [3], L C Villa Olivares [4]

[1] Department of Rehabilitation Medicine, Medical Director of Physis Clinics, Chihuahua, Mexico,
[2] Department of Rheumatology, Hospital Ángeles, Chihuahua, Mexico,
[3] Department of Orthopedics and Traumatology, Hospital Central Universitario, Chihuahua, Mexico,
[4] Department of Radiology, Civil Pensions of the State of Chihuahua, Mexico.

Address of Correspondence
Dr. A A Flores Salinas,
Department of Rehabilitation Medicine, Medical Director of Physis Clinics, Chihuahua, Mexico.
Email- drazaelflores@hotmail.com


Abstract

Patellar tendon ruptures are rare injuries and are more commonly associated with predisposing factors and previous surgical procedures than with direct trauma. Acute partial-thickness tears are usually treated with immobilization and rehabilitation. The literature recommends surgical management of partial ruptures of the patellar tendon after 6 months of failure of conservative treatments and in acute cases with a compromise >50–55% of the tendon. Radial pressure wave therapy is a safe, non-invasive technique with scientific support in tissue regeneration; it is found as one of the therapeutic alternatives for the management of tendinopathy and partial ruptures of the patellar tendon. The present case report shows the effectiveness of radial pressure wave therapy in a shear injury of the patellar tendon, with a compromise of at least 70%. We have not found similar cases previously reported in the literature, highlighting its relevance.
Keywords: Patellar tendon, Radial pressure waves, Patellar tendon rupture, Cutting injury


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How to Cite this article: Salinas AAF, Cordero GCR, Rodriguez LBG, and Olivares LCV. Regeneration of the Patellar Tendon with Radial Pressure Waves in a Sharp Injury: A Case Report. Journal of Regenerative Science 2024;January-June;4(1):20-23.

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