Use of Focused Shock Waves in an Acute Talar Head Fracture

/0 Comments/in /by

Case Report | Vol 4 | Issue 1 |  January-June 2024 | page: 24-26 | Osvaldo Valle

DOI: https://doi.org/10.13107/jrs.2024.v04.i01.129

Author: Osvaldo Valle [1]

[1] Department of Orthopedic Surgeon Surgery, Ankle and Foot Team, MEDS Clinic, Santiago de Chile; President of ACHITOC (Chilean Association of Tissue Engineering and Shock Waves).

Address of Correspondence
Dr. Osvaldo Valle,
Department of Orthopedic Surgeon, Ankle and Foot Team, MEDS Clinic, Santiago de Chile; President of ACHITOC (Chilean Association of Tissue Engineering and Shock Waves).
E-mail: tovato@gmail.com

Abstract

Talar fractures are rare and can be difficult to manage. Even in the absence of complications, the treatment of this type of injury can be prolonged and uncomfortable for the patient. Focused shock waves have been shown to be effective in the treatment of delayed unions and non-unions. In this case report, we share our experience with the use of focused shock waves in an acute talus fracture in a patient with risk factors for healing.
Keywords: Talus, Talar fractures, Shock waves, Bone marrow edema

References:

1. Caracchini G, Pietragalla M, De Renzis A, Galluzzo M, Carbone M, Zappia M, Russo A, Greco F, Miele V. Talar fractures: radiological and CT evaluation and classification systems. Acta Biomed. 2018 Jan 19;89(1-S):151-165. doi: 10.23750/abm.v89i1-S.7019. PMID: 29350644; PMCID: PMC6179081.
2. Anderson MR, Flemister AS, Ketz JP. Operative Treatment of Talar Head Fractures: Surgical Technique. J Orthop Trauma. 2018 Aug;32(8):e334-e338. doi: 10.1097/BOT.0000000000001178. Erratum in: J Orthop Trauma. 2019 Oct;33(10):e409. doi: 10.1097/BOT.0000000000001596. PMID: 29664882.
3. Pradhan A, Najefi A, Patel A, Vris A, Heidari N, Malagelada F, Parker L, Jeyaseelan L. Complications after talus fractures: A trauma centre experience. Injury. 2023 Feb;54(2):772-777. doi: 10.1016/j.injury.2022.12.013. Epub 2022 Dec 15. PMID: 36543737.
4. Schwartz AM, Runge WO, Hsu AR, Bariteau JT. Fractures of the Talus: Current Concepts. Foot Ankle Orthop. 2020 Feb 13;5(1):2473011419900766. doi: 10.1177/2473011419900766. PMID: 35097362; PMCID: PMC8697161.
5. Moya D, Ramón S, Schaden W, Wang CJ, Guiloff L, Cheng JH. The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders. J Bone Joint Surg Am. 2018 Feb 7;100(3):251-263. doi: 10.2106/JBJS.17.00661. PMID: 29406349.
6. Wang CJ, Liu HC, Fu TH. The effects of extracorporeal shockwave on acute high-energy long bone fractures of the lower extremity. Arch Orthop Trauma Surg. 2007 Feb;127(2):137-42. doi: 10.1007/s00402-006-0236-0. Epub 2006 Oct 13. PMID: 17053946.
7. Vallier HA. Fractures of the Talus: State of the Art. J Orthop Trauma. 2015 Sep;29(9):385-92. doi: 10.1097/BOT.0000000000000378. PMID: 26299809.
8. Higgins TF, Baumgaertner MR. Diagnosis and treatment of fractures of the talus: a comprehensive review of the literature. Foot Ankle Int. 1999 Sep;20(9):595-605. doi: 10.1177/107110079902000911. PMID: 10509689.
9. Jordan RK, Bafna KR, Liu J, Ebraheim NA. Complications of Talar Neck Fractures by Hawkins Classification: A Systematic Review. J Foot Ankle Surg. 2017 Jul-Aug;56(4):817-821. doi: 10.1053/j.jfas.2017.04.013. PMID: 28633784.
10. Ohl X, Harisboure A, Hemery X, Dehoux E. Long-term follow-up after surgical treatment of talar fractures: Twenty cases with an average follow-up of 7.5 years. Int Orthop. 2011 Jan;35(1):93-9. doi: 10.1007/s00264-009-0930-y. Epub 2009 Dec 22. PMID: 20033158; PMCID: PMC3014484.
11. Vallier HA, Nork SE, Barei DP, Benirschke SK, Sangeorzan BJ. Talar neck fractures: results and outcomes. J Bone Joint Surg Am. 2004 Aug;86(8):1616-24. PMID: 15292407.
12. Zura R, Mehta S, Della Rocca GJ, Steen RG. Biological Risk Factors for Nonunion of Bone Fracture. JBJS Rev. 2016 Jan 5;4(1):e5. doi: 10.2106/JBJS.RVW.O.00008. PMID: 27490008.
13. Rinonapoli G, Pace V, Ruggiero C, Ceccarini P, Bisaccia M, Meccariello L, Caraffa A. Obesity and Bone: A Complex Relationship. Int J Mol Sci. 2021 Dec 20;22(24):13662. doi: 10.3390/ijms222413662. PMID: 34948466; PMCID: PMC8706946.
14. Liu SH, Cerri-Droz P, Ling K, Loyst RA, Wang KE, Tsouris N, Komatsu DE, Wang ED. Chronic Steroid Use, Complications, and Readmission Following Open Reduction Internal Fixation of Distal Radius Fracture. J Hand Surg Glob Online. 2023 Aug 19;5(6):757-762. doi: 10.1016/j.jhsg.2023.07.007. PMID: 38106944; PMCID: PMC10721537.
15. Moonen L, Gorter E, Schipper I. The importance of vitamin D in treatment of fracture non-union: A case report. Nutrition. 2021 Jul-Aug;87-88:111192. doi: 10.1016/j.nut.2021.111192. Epub 2021 Feb 10. PMID: 33761443.
16. Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):585-91. doi: 10.1016/j.beem.2011.05.002. PMID: 21872800.
17. Wang CJ, Wang FS, Yang KD. Biological effects of extracorporeal shockwave in bone healing: a study in rabbits. Arch Orthop Trauma Surg. 2008 Aug;128(8):879-84. doi: 10.1007/s00402-008-0663-1. Epub 2008 Jun 17. PMID: 18560855.

 

How to Cite this article: Valle O. Use of focused shock waves in an acute talar head fracture. Journal of Regenerative Science 2024;January-June;4(1):24-26.

 

[Article Text HTML]       [Full Text PDF] 

20 Years of Treatment of Bone Non-Unions and Delayed Unions with Shock Waves

/0 Comments/in /by

??? | Vol 4 | Issue 1 |  January-June 2024 | page: 27-30| Paulo F Kertzman

DOI: https://doi.org/10.13107/jrs.2024.v04.i01.131

Author: Paulo F Kertzman [1]

[1] Departamento de Ortopedia, Santa Casa de São Paulo, São Paulo, SP, Brazil.

Address of Correspondence
Dr. Paulo F Kertzman
Departamento de Ortopedia, Santa Casa de São Paulo, São Paulo, SP, Brazil.
E-mail: paulofkertzman@uol.com.br

Abstract

The treatment of bone non-unions continues to be complex and prolonged in many cases. The advent of the use of mechanical waves has made it possible, through the phenomenon of mechanotransduction, to have a non-invasive tool with a low rate of complications.
This study analyzes the experience of the last 20 years with the use of shock waves.

Keywords: Non-union, shock waves, Delayed union, Mechanotransduction

References:

1- Bell A, Templeman D, Weinlein JC. Nonunion of the femur and Tibia: An update. Orthop Clin North Am 2016;47:365-75.
2- Ekegren CL, Edwards ER, de Steiger R, Gabbe BJ. Incidence, Costs and Predictors of Non-Union, Delayed Union and Mal-Union Following Long Bone Fracture. Int J Environ Res Public Health. 2018 Dec 13;15(12):2845. doi: 10.3390/ijerph15122845. PMID: 30551632; PMCID: PMC6313538.
3- Rupp M, Biehl C, Budak M, Thormann U, Heiss C, Alt V. Diaphyseal long bone nonunions – Types, aetiology, economics, and treatment recommendations. Int Orthop 2017;42:247-58.
4- Schaden W, Mittermayr R, Haffner N, Smolen D, Gerdesmeyer L, Wang CJ. Extracorporeal shockwave therapy (ESWT)–First choice treatment of fracture non-unions? Int J Surg 2015;24:179-83.
5- Wang CJ, Chen HS, Chen CE, Yang KD. Treatment of nonunions of long bone fractures with shock waves. Clin Orthop Relat Res 2001;387:95-101.
6- Haupt G, Haupt A, Gerety B, Chvapil M. Enhancement of fracture healing with extracorporeal shock waves. J Urol 1990;158:4.
7- Valchanou VD, Michailov P. High energy shock waves in the treatment of delayed and nonunion of fractures. Int Orthop. 1991;15(3):181-4. doi: 10.1007/BF00192289. PMID: 1743828.
8- Main G, Haupt A, Ekkernkamp A, Gerety B, Chvapil M. Influence of shock waves on fracture healing. Urology 1992;39:529-32.
9- Kertzman P, Lenza M, Pedrinelli A, Ejnisman B. Shockwave treatment for musculoskeletal diseases and bone consolidation: Qualitative analysis of the literature. Rev Bras Ortop 2015;50:3-8.
10- Cheng JH, Wang CJ. Biological mechanism of shockwave in bone. Int J Surg. 2015 Dec;24(Pt B):143-6. doi: 10.1016/j.ijsu.2015.06.059. Epub 2015 Jun 25. PMID: 26118613.
11- Schnurrer-Luke-Vrbanić T, Avancini-Dobrović V, Sosa I, Cvijanovic O, Bobinac D. Effect of radial shock wave therapy on long bone fracture repair. J Biol Regul Homeost Agents. 2018 Jul-Aug;32(4):875-879. PMID: 30043570.
12- d’Agostino MC, Craig K, Tibalt E, Respizzi S. Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction. Int J Surg. 2015 Dec;24(Pt B):147-53. doi: 10.1016/j.ijsu.2015.11.030. Epub 2015 Nov 28. PMID: 26612525.
13- Wang CJ, Wang FS, Yang KD. Biological effects of extracorporeal shockwave in bone healing: a study in rabbits. Arch Orthop Trauma Surg. 2008 Aug;128(8):879-84. doi: 10.1007/s00402-008-0663-1. Epub 2008 Jun 17. PMID: 18560855.
14- Ha CH, Kim S, Chung J, An SH, Kwon K. Extracorporeal shock wave stimulates expression of the angiogenic genes via mechanosensory complex in endothelial cells: mimetic effect of fluid shear stress in endothelial cells. Int J Cardiol. 2013 Oct 9;168(4):4168-77. doi: 10.1016/j.ijcard.2013.07.112. Epub 2013 Aug 1. PMID: 23915523.
15- Xu JK, Chen HJ, Li XD, Huang ZL, Xu H, Yang HL, Hu J. Optimal intensity shock wave promotes the adhesion and migration of rat osteoblasts via integrin β1-mediated expression of phosphorylated focal adhesion kinase. J Biol Chem. 2012 Jul 27;287(31):26200-12. doi: 10.1074/jbc.M112.349811. Epub 2012 May 31. PMID: 22654119; PMCID: PMC3406705.
16- Sun D, Junger WG, Yuan C, Zhang W, Bao Y, Qin D, Wang C, Tan L, Qi B, Zhu D, Zhang X, Yu T. Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors. Stem Cells. 2013 Jun;31(6):1170-80. doi: 10.1002/stem.1356. PMID: 23404811; PMCID: PMC4243484.
17- Wang FS, Wang CJ, Chen YJ, Chang PR, Huang YT, Sun YC, et al. Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts. J Biol Chem 2004;279:10331-7.
18- Kusnierczak D, Brocai DR, Vettel U, Loew M. Der Einfluss der extrakorporalen Stosswellenapplikation (ESWA) auf das biologische Verhalten von Knochenzellen in vitro [Effect of extracorporeal shockwave administration on biological behavior of bone cells in vitro]. Z Orthop Ihre Grenzgeb. 2000 Jan-Feb;138(1):29-33. German. doi: 10.1055/s-2000-10109. PMID: 10730360.
19- Császár NB, Angstman NB, Milz S, Sprecher CM, Kobel P, Farhat M, Furia JP, Schmitz C. Radial Shock Wave Devices Generate Cavitation. PLoS One. 2015 Oct 28;10(10):e0140541. doi: 10.1371/journal.pone.0140541. PMID: 26509573; PMCID: PMC4625004.
20- Xu ZH, Jiang Q, Chen DY, Xiong J, Shi DQ, Yuan T, Zhu XL. Extracorporeal shock wave treatment in nonunions of long bone fractures. Int Orthop. 2009 Jun;33(3):789-93. doi: 10.1007/s00264-008-0553-8. Epub 2008 Apr 25. PMID: 18437381; PMCID: PMC2903117.
21- Bara T, Synder M. Nine-years experience with the use of shock waves for treatment of bone union disturbances. Ortop Traumatol Rehabil. 2007 May-Jun;9(3):254-8. English, Polish. PMID: 17721422.
22- Rompe JD, Rosendahl T, Schöllner C, Theis C. High-energy extracorporeal shock wave treatment of nonunions. Clin Orthop Relat Res. 2001 Jun;(387):102-11. doi: 10.1097/00003086-200106000-00014. PMID: 11400870.
23- Schaden W, Fischer A, Sailler A. Extracorporeal shock wave therapy of nonunion or delayed osseous union. Clin Orthop Relat Res 2001;387:90-4.
24- Vulpiani MC, Vetrano M, Conforti F, Minutolo L, Trischitta D, Furia JP, Ferretti A. Effects of extracorporeal shock wave therapy on fracture nonunions. Am J Orthop (Belle Mead NJ). 2012 Sep;41(9):E122-7. PMID: 23365814.
25- Kuo SJ, Su IC, Wang CJ, Ko JY. Extracorporeal shockwave therapy (ESWT) in the treatment of atrophic non-unions of femoral shaft fractures. Int J Surg. 2015 Dec;24(Pt B):131-4. doi: 10.1016/j.ijsu.2015.06.075. Epub 2015 Jul 9. PMID: 26166737.
26- Moya D, Ramón S, Schaden W, Wang CJ, Guiloff L, Cheng JH. The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders. J Bone Joint Surg Am. 2018 Feb 7;100(3):251-263. doi: 10.2106/JBJS.17.00661. PMID: 29406349.
27- Kertzman P, Császár NB, Furia JP, Schmitz C. Radial extracorporeal shock wave therapy is efficient and safe in the treatment of fracture nonunions of superficial bones: A retrospective case series. J Orthop Surg Res 2017;12:164.
28- Cacchio A, Giordano L, Colafarina O, Rompe JD, Tavernese E, Ioppolo F, et al. Extracorporeal shock-wave therapy compared with surgery for hypertrophic long-bone nonunions. J Bone Joint Surg Am 2009;91:2589-97.
29- Furia JP, Juliano PJ, Wade AM, Schaden W, Mittermayr R. Shock wave therapy compared with intramedullary screw fixation for nonunion of proximal fifth metatarsal metaphyseal-diaphyseal fractures. J Bone Joint Surg Am 2010;92:846-54.
30- Quadlbauer S, Pezzei C, Beer T, Jurkowitsch J, Keuchel T, Schlintner C, Schaden W, Hausner T, Leixnering M. Treatment of scaphoid waist nonunion by one, two headless compression screws or plate with or without additional extracorporeal shockwave therapy. Arch Orthop Trauma Surg. 2019 Feb;139(2):281-293. doi: 10.1007/s00402-018-3087-6. Epub 2018 Dec 6. PMID: 30523445.
31- Notarnicola A, Moretti L, Tafuri S, Gigliotti S, Russo S, Musci L, Moretti B. Extracorporeal shockwaves versus surgery in the treatment of pseudoarthrosis of the carpal scaphoid. Ultrasound Med Biol. 2010 Aug;36(8):1306-13. doi: 10.1016/j.ultrasmedbio.2010.05.004. PMID: 20691920.
32- Schmitz C, Császár NB, Milz S, Schieker M, Maffulli N, Rompe JD, Furia JP. Efficacy and safety of extracorporeal shock wave therapy for orthopedic conditions: a systematic review on studies listed in the PEDro database. Br Med Bull. 2015;116(1):115-38. doi: 10.1093/bmb/ldv047. Epub 2015 Nov 18. PMID: 26585999; PMCID: PMC4674007.
33- Birnbaum K, Wirtz DC, Siebert CH, Heller KD. Use of extracorporeal shock-wave therapy (ESWT) in the treatment of non-unions. A review of the literature. Arch Orthop Trauma Surg. 2002 Jul;122(6):324-30. doi: 10.1007/s00402-001-0365-4. Epub 2002 Mar 12. PMID: 12136295.
34- Petrisor B, Lisson S, Sprague S. Extracorporeal shockwave therapy: A systematic review of its use in fracture management. Indian J Orthop. 2009 Apr;43(2):161-7. doi: 10.4103/0019-5413.50851. PMID: 19838365; PMCID: PMC2762266.
35- Willems A, van der Jagt OP, Meuffels DE. Extracorporeal Shock Wave Treatment for Delayed Union and Nonunion Fractures: A Systematic Review. J Orthop Trauma. 2019 Feb;33(2):97-103. doi: 10.1097/BOT.0000000000001361. PMID: 30570614.
36- Schnurrer-Luke-Vrbanic T, Avancini-Dobrovic V, Sosa I, Cvijanovic O, Bobinac D. VEGF-A expression in soft tissues repaired by shockwave therapy: differences between modalities. J Biol Regul Homeost Agents. 2018 May-Jun;32(3):583-588. PMID: 29921384.
37- Gollwitzer H, Gloeck T, Roessner M, Langer R, Horn C, Gerdesmeyer L, et al. Radial extracorporeal shock wave therapy (rESWT) induces new bone formation in vivo: Results of an animal study in rabbits. Ultrasound Med Biol 2013;39:126-33.
38- Diaz-Rodriguez L, Garcia-Marinez O, Arroyo-Morales M, Ramos-Torrecillas J, De Luna-Bertos E, Ruiz C. Effect of radial extracorporeal shock wave therapy on proliferation, cell viability and phagocytosis of human osteoblasts (MG63). Adv Sci Lett 2012;17:325-9.
39- Silk ZM, Alhuwaila RS, Calder JD. Low-energy extracorporeal shock wave therapy to treat lesser metatarsal fracture nonunion: Case report. Foot Ankle Int 2012;33:1128-32.
40- Kertzman PF, Fucs PM. Does radial shock wave therapy works in pseudarthrosis? Prospective analysis of forty four patients. Int Orthop 2021;45:43-9.

 

How to Cite this article: Kertzman PF. 20 Years of Treatment of Non-Unions and Delayed Unions with Shock Waves. Journal of Regenerative Science 2024;January-June;4(1):27-30.

 

[Article Text HTML]       [Full Text PDF] 

Extracorporeal Shock Wave Treatment and Multimodal Pain Management for Tarsal Tunnel Syndrome Associated with Plantar Fasciitis

/0 Comments/in /by

Case Report | Vol 4 | Issue 1 |  January-June 2024 | page: 31-34 | Ricardo Kobayashi

DOI: https://doi.org/10.13107/jrs.2024.v04.i01.133

 

Author: Ricardo Kobayashi [1]

[1] Department of Neurology, Pain Center, University of São Paulo, Brazil.

Address of Correspondence
Dr. Ricardo Kobayashi,
Department of Neurology, Pain Center, University of São Paulo, Brazil.
E-mail: koba@globo.com

Abstract

Introduction: Plantar fasciitis (PF) is an important cause of musculoskeletal pain and radial pressure waves (RPWs) can be used for patients not improving after 3 months of other non-operative measures. However, in refractory cases of PT, it is imperative to investigate possible differential diagnoses and one of its important differential diagnoses is tarsal tunnel syndrome (TTS). TTS is a rare but important condition which is regularly under diagnosed leading to a range of symptoms affecting the plantar aspect of the foot typically associated with a neuropathic pain pattern.
Case Report: We report a case of PF with TTS and associated neuropathic components. At first, nortriptyline 50 mg and 5% lidocaine patch were used, which improved the neuropathic pattern. After that, three RPW sessions were conducted at weekly intervals, with energy between 2 and 3 bars, frequency between 5 and 7 hertz. In addition to the area of greatest pain in the plantar fascia, treatment was also applied to the myofascial trigger points of the triceps surae and posterior tibial muscles. Three months after the last RPW session, the patient reported a 90% improvement in pain intensity, without limitations in daily activities.
Conclusion: This case highlights the importance of differential diagnoses of PF, especially before the indication of RPW in refractory cases. In addition to the neuropathic pattern associated with TTS, neuropathic pain associated with tendinopathies of the lower limbs is common (1/4 of cases) and needs to be identified and treated in conjunction with tendinopathy for a more effective result.
Keywords: Chronic pain, Plantar fasciitis, Tarsal tunnel syndrome, Mixed pain, Neuropathic pain, Shockwaves

References:

1. Charles R, Fang L, Zhu R, Wang J. The effectiveness of shockwave therapy on patellar tendinopathy, Achilles tendinopathy, and plantar fasciitis: a systematic review and meta-analysis. Front Immunol. 2023 Aug 16;14:1193835. doi: 10.3389/fimmu.2023.1193835. PMID: 37662911; PMCID: PMC10468604.
2. Wheeler PC. Up to a quarter of patients with certain chronic recalcitrant tendinopathies may have central sensitisation: a prospective cohort of more than 300 patients. Br J Pain. 2019 Aug;13(3):137-144. doi: 10.1177/2049463718800352. Epub 2018 Sep 21. PMID: 31308939; PMCID: PMC6613072.
3. Ahmad M, Tsang K, Mackenney PJ, Adedapo AO. Tarsal tunnel syndrome: A literature review. Foot Ankle Surg. 2012 Sep;18(3):149-52. doi: 10.1016/j.fas.2011.10.007. Epub 2011 Dec 21. PMID: 22857954.
4. Wheeler PC. Neuropathic pain may be common in chronic lower limb tendinopathy: a prospective cohort study. Br J Pain. 2017 Feb;11(1):16-22. doi: 10.1177/2049463716680560. Epub 2016 Nov 24. PMID: 28386400; PMCID: PMC5370628.
5. Camargo LS, Kobayashi R. Case report: Extracorporeal shock wave treatment in plantar fasciitis with an associated neuropathic component. How to optimize the result? J Regen Sci 2022;2:21-3.
6. Bouhassira D, Attal N, Alchaar H, Boureau F, Brochet B, Bruxelle J, Cunin G, Fermanian J, Ginies P, Grun-Overdyking A, Jafari-Schluep H, Lantéri-Minet M, Laurent B, Mick G, Serrie A, Valade D, Vicaut E. Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (Dn4). Pain. 2005 Mar;114(1-2):29-36. doi : 10.1016/j.pain.2004.12.010. Epub 2005 Jan 26. PMID: 15733628.
7. Santos JG, Brito JO, de Andrade DC, Kaziyama VM, Ferreira KA, Souza I, et al. Translation to Portuguese and validation of the Douleur Neuropathique 4 questionnaire. J Pain. 2010 May;11(5):484-90. doi: 10.1016/j.jpain.2009.09.014. Epub 2009 Dec 16. PMID: 20015708.
8. Aqil A, Siddiqui MR, Solan M, Redfern DJ, Gulati V, Cobb JP. Extracorporeal shock wave therapy is effective in treating chronic plantar fasciitis: a meta-analysis of RCTs. Clin Orthop Relat Res. 2013 Nov;471(11):3645-52. doi: 10.1007/s11999-013-3132-2. Epub 2013 Jun 28. PMID: 23813184; PMCID:PMC3792262.
9. Sun J, Gao F, Wang Y, Sun W, Jiang B, Li Z. Extracorporeal shock wave therapy is effective in treating chronic plantar fasciitis: A meta-analysis of RCTs. Medicine (Baltimore). 2017Apr;96(15):e6621. doi: 10.1097/MD.0000000000006621. PMID: 28403111; PMCID: PMC5403108.
10. Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D et al. Neuropathic pain. Nat Rev Dis Primers. 2017 Feb 16;3:17002. doi: 10.1038/nrdp.2017.2. PMID: 28205574; PMCID: PMC5371025.
11. Attal N, Cruccu G, Baron R, Haanpää M, Hansson P, Jensen TS, Nurmikko T. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010 Sep;17(9):1113-e88. doi: 10.1111/j.1468-1331.2010.02999.x. Epub 2010 Apr 9. PMID: 20402746.
12. Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol.2015 Feb;14(2):162-73. doi: 10.1016/S1474-4422(14)70251-0. Epub 2015 Jan 7. PMID: 25575710; PMCID: PMC4493167.
13. Finnerup NB. Nonnarcotic Methods of Pain Management N Engl J Med. 2019 Jun 20;380(25):2440-2448. doi: 10.1056/NEJMra1807061. PMID: 31216399.

 

How to Cite this article: Kobayashi R | Extracorporeal Shock Wave Treatment and Multimodal Pain Management for Tarsal Tunnel Syndrome Associated with Plantar Fasciitis. Journal of Regenerative Science 2024;January-June;4(1):31-34

[Article Text HTML]       [Full Text PDF] 

Errors in Shock Wave Theory Can Impact Clinical Outcomes

/0 Comments/in /by

Bibliographic Analysis | Vol 4 | Issue 1 |  January-June 2024 | page: 35-36 | Achim M. Loske, Daniel Moya

DOI: https://doi.org/10.13107/jrs.2024.v04.i01.135

 

Author: Achim M. Loske [1], Daniel Moya [2]

[1] Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Juriquilla, Querétaro, México,
[2] Department of Orthopaedics, Hospital Británico de Buenos Aires, Argentina.

Address of Correspondence
Dr. Daniel Moya,
Department of Orthopaedics, Hospital Británico de Buenos Aires, Argentina.
E-mail: drdanielmoya@yahoo.com.ar

Abstract

The mechanical waves that are used therapeutically are well defined from the point of view of physics. The differences between focused and radial waves are very important, however there is enormous confusion in the literature.
In the present bibliographic analysis we make a critical comment on a publication in which a pneumatic source is illustrated and presented as generating focused shock waves.
We believe that every effort should be made to be strict in definitions, not only because science is based on the search for truth, but also because errors in shock wave theory can impact clinical outcomes.

References:

1. An S, Li J, Xie W, Yin N, Li Y, Hu Y. Extracorporeal shockwave treatment in knee osteoarthritis: Therapeutic effects and possible mechanism. Biosci Rep 2020;40:BSR20200926.
2. Moya D, Ramón S, Schaden W, Wang CJ, Guiloff L, Cheng JH. The role of extracorporeal shockwave treatment in musculoskeletal disorders. J Bone Joint Surg Am 2018;100:251-63.
3. Loske AM. Medical and Biomedical Applications of Shock Waves. Cham, Switzerland: Springer International; 2017.
4. Ueberle F, Rad A. Ballistic pain therapy devices: Measurement of pressure pulse parameters. Biomed Tech 2012;57:700-3.
5. International Society for Medical Shockwave Therapy. Physical Principles of ESWT Basic Physical Principles. Available from: https://www.shockwavetherapy.org/about-eswt/physical-principles-of-eswt [Last accessed on 2021 Jan 26].
6. International Society for Medical Shockwave Therapy. ISMST Recommendations-Terms and Definitions. Available from: https://www.shockwavetherapy.org/fileadmin/user_upload/dokumente/pdfs/formulare/consensus_mbradial_pressure_wave_2017_ss.pdf [Last accessed on 2021 Jan 26].
7. Federación Ibero-Latinoamericana de Ondas de Choque e Ingeniería Tisular (Onlat) Ondas de Choque en Medicina: La Nueva Frontera. Available from: https://onlat.net/?page_id=2491 [Last accessed on 2021 Jan 26].
8. European Commission DG Health and Consumer. Medical Devices: Guidance Document. Classification of Medical Devices. MEDDEV 2. 4/1 Rev. 9; 2010. Available from: https://pdf4pro.com/download/medical-devices-guidance-document-6fa97.html [Last accessed on 2021 Jan 26].

How to Cite this article:  Loske AM, Moya D. Errors in Shock Wave Theory Can Impact Clinical Outcomes. Journal of Regenerative Science 2024;January-June;4(1):35-36.

[Article Text HTML]       [Full Text PDF] 

China, The Awakened Giant

/0 Comments/in /by

Editorial | Vol 3 | Issue 2 |  July-December 2023 | page: 01-02 | Daniel Moya

DOI: https://doi.org/10.13107/jrs.2023.v03.i02.85

Author: Daniel Moya [1]

[1] Department of Orthopaedics. Buenos Aires British Hospital, Argentina.

Address of Correspondence
Dr. Daniel Moya,
Department of Orthopaedics. Buenos Aires British Hospital, Argentina.
E-mail: drdanielmoya@yahoo.com.ar

Editorial:

The history of Chinese medicine is as long and legendary as that of the country itself. Its origins date back 3000 years [1]. Scientific knowledge and medical practice has gone through numerous stages.
Between the 8th and 3rd centuries BC, China went through a period of great cultural and intellectual development called the “Hundred Schools of Thought” [2]. An attempt was made to seek the explanation of the phenomena of the universe in nature itself, leaving aside explanations based on magic and myths [2]. The new ideas discussed and developed during this period have profoundly influenced philosophical views and lifestyles up to the present day in East Asian countries.
A fundamental milestone was the publication of “Huangdi Neijing“. Also known as the “Inner Canon of Huangdi“ or “Inner Canon of the Yellow Emperor“, it is the earliest surviving work on Chinese medicine[3]. Its author, Emperor Huangdi, is not only considered the initiator of Chinese Traditional Medicine but also the father of Chinese civilization.
Caring for the health of the population has been a priority in this country throughout the centuries. As a history lover, it is difficult for me to find another example of a nation embarking on an unequal war to defend its public health. This happened when the Western powers, led by the British Empire, sought to create opium addiction among the Chinese population in order to balance their trade balance by trafficking drugs [4]. These infamous conflicts went down in history as the “Opium Wars” and cost the lives of thousands of Chinese citizens.
In the last decades, China’s healthcare system has made great achievements in the management of medical services and public health for the Chinese people[5]. Average life expectancy at birth was 35 years before the founding of new China, and it reached 77.0 years in 2018 [6]. The projected life expectancy at birth in mainland China in 2035 is 81,3 years [7].
On April 6, 2009, China presented an action plan to undertake a radical and ambitious reform of the health system [8]. The goal is to achieve universal health coverage.
The history of shock waves in this country is a reflection of the described dynamism and historical background. The beginnings of its use in China can be traced back to the 1980s in the urological field. Prof. Xing Gengyan was the pioneer of indications in musculoskeletal pathology starting in 1993. Since that moment he has been a promoter not only of research and clinical applications, but also of medical education. In 2019, he organized in Beijing the largest international shock wave congress in history. It is a great honor that he has contributed to this issue by writing about the development of this therapeutic practice in China.
In parallel with healthcare and academic development, the Chinese industry has risen to the occasion by providing high-quality devices.
The content of this volume reflects not only the ability of our Chinese colleagues but also their openness to the world and their generosity in sharing information. Numerous universities and hospitals from different regions throughout China have collaborated selflessly. This could not have been accomplished without the monumental task of Dr. Sun Wei, our Guest Editor.
Napoleon Bonaparte is credited with the phrase “China is a sleeping giant, when she wakes she will shake the world“. Two hundred years later the giant is awake and brimming with energy.

References

[1] Reyes G Ariel E. Evolución Histórica de la Medicina Tradicional China. Comunidad y Salud [Internet]. 2008 Dic [citado 2023 Dic 27] ; 6( 2 ): 42-49. Disponible en: http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S1690-32932008000200005&lng=es
[2] Orígenes de la Medicina China. Escuela Li Ping de acupuntura y Medicina Tradicional China. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://escuelaliping.com/wp-content/uploads/2013/10/Tema1.pdf
[3] Huang di nei jing su wen. Library of the congress. https://www.loc.gov/item/2021666312
[4] Travis Hanes III W, and Sanello F. The Addiction of One Empire and the Corruption of Another. Ed. Sourcebooks. 2004. ISBN-13 ‏ : ‎ 978-1402201493
[5] Chen C, Liu M. Achievements and Challenges of the Healthcare System in China. Cureus. 2023 May 15;15(5):e39030. doi: 10.7759/cureus.39030. PMID: 37378106; PMCID: PMC10292030.
[6] Yuan, X., Gao, Y. Demographic transition and economic miracles in China: an analysis based on demographic perspective. IJEPS 14, 25–45 (2020). https://doi.org/10.1007/s42495-019-00030-0
[7] Bai R, Liu Y, Zhang L, Dong W, Bai Z, Zhou M. Projections of future life expectancy in China up to 2035: a modelling study. Lancet Public Health. 2023 Dec;8(12):e915-e922. doi: 10.1016/S2468-2667(22)00338-3. Epub 2023 Mar 30. PMID: 37004714; PMCID: PMC10188127.
[8]China’s latest revolution: Basic health care for all. https://www.ilo.org/global/about-the-ilo/mission-and-objectives/features/WCMS_188582/lang–en/index.htm

How to Cite this article: Moya D | China, The Awakened Giant. | Journal of Regenerative Science | Jul-Dec 2023; 3(2): 01-02.

  (Abstract    Full Text HTML)   (Download PDF)

The History of Shock Wave Medicine Development in China

/0 Comments/in /by

Editorial | Vol 3 | Issue 2 |  July-December 2023 | page: 03-04 | Shuitao Liu, Gengyan Xing

DOI: https://doi.org/10.13107/jrs.2023.v03.i02.87

Author: Shuitao Liu [1], Gengyan Xing [2]

[1] Department of Traumatic Orthopedics, Armed Police Characteristic Medical Center., Tianjin, China,
[2] Corresponding author: Gengyan Xing, Department of Orthopedic, The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, China.

Address of Correspondence
Dr. Gengyan Xing,
Department of Orthopedic, The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing,
China.
E-mail: xgy1350138@163.com

Editorial

The development of shock wave medicine in China can be traced back to the 1980s. At that time, shock waves were applied to treat urinary tract stones with good results. In 1993, Professor Xing Gengyan pioneered the application of extracorporeal shock wave therapy for humeral epicondylitis, marking a significant milestone in the advancement of shock wave medicine in China. With the deepening of research on shock waves and technological advancements, the indications for shock wave medicine have been continuously expanded, achieving good results in treating bone tissue diseases such as delayed fracture healing and non-union. To further promote the experience of shock wave therapy, Professor Xing Gengyan successively held 8 national continuing education programs on “Extracorporeal Shock Wave Therapy for Bone and Muscle Disorders,” training thousands of doctors who mastered shock wave therapy techniques. With the conduct of numerous clinical studies and accumulation of data, the China National Medical Products Administration approved the domestic production of extracorporeal shock wave therapy machines for treating orthopedic diseases in August 2000, marking the official entry of shock wave medicine into a high-speed development phase in China.
As clinical applications continue to advance and expand, Chinese scholars have begun to explore the mechanisms of action of shock waves. In 2004, Professor Xing Ganyan’s research on “Osteoblast Mechanochemical Signal Transduction and Related Gene Expression Following ESWT” was funded by the National Natural Science Foundation of China, resulting in a wealth of published findings. In 2007, Professor Xing Ganyan edited and published the first monograph on shock wave medicine, <Extracorporeal Shock Wave Therapy for Bone and Muscle Diseases (First Edition)>, which consists of two parts and eight chapters. This comprehensive summary of over a decade of clinical application experience and foundational research laid the foundation for shock wave medicine in China.
With the rapid advancement of China’s medical level, Chinese scholars’ research on shock waves has gradually gained global recognition. A significant number of papers on shock waves published by Chinese scholars has been indexed, and their research achievements have been communicated at international conferences. Concurrently, as the depth of research on shock wave therapy increases and instruments advance, shock waves are no longer confined to treating urinary tract stones, non-unions, osteonecrosis, and tendinopathy [1-4]. They have also achieved promising results in treating myocardial infarction, skin ulcers, tumors, nerve injuries, and male dysfunction, among others.
In December 2013, the Chinese Shock Wave Medicine Professional Committee was established in Beijing, with Professor Xing Gengyan serving as the inaugural Chairman. Since then, shock wave medicine has had an independent academic organization. Building on past experiences, in 2014, the <Expert Consensus on Extracorporeal Shock Wave Therapy for Bone and Muscle Diseases> was released [5], significantly advancing the scientific and standardized development of shock wave medicine. In 2015, the <Extracorporeal Shock Wave Therapy for Bone and Muscle Diseases (Second Edition)> was published, expanding the volume to 5 articles and 19 chapters, with a significant addition of numerous recent research findings. In July 2016, at the annual meeting of the international society for medical shock wave treatment (ISMST) held in Malaysia, Professor Xing Gengyan was elected as the President of the ISMST. China secured the hosting rights for the 22nd annual conference in 2019, signifying that China is at the forefront of shock wave medicine development worldwide.
The year 2019 marked the most memorable year in the history of shock wave development in Chinese medicine. Building upon the previous two editions of the <Expert Consensus on Extracorporeal Shock Wave Therapy for Bone and Muscle Diseases>, Chinese scholars integrated evidence-based medical experiences and released the <Chinese Guidelines for Extracorporeal Shock Wave Therapy for Bone and Muscle Diseases (2019 Edition) [6], thereby standardizing and scientifically advancing the application of shock waves in China. In May of the same year, the ISMST 22nd International Congress on Medical Shock Waves convened in Beijing, attended by over 1,200 experts and scholars from nearly 30 countries. This was the largest-attended conference in the history of shock wave medicine, covering the broadest range of academic interests and delving into the most in-depth discussions on various research topics, significantly advancing the development of shock wave medicine in China.
Currently, over 3,000 hospitals in China possess extracorporeal shock wave therapy systems, covering treatment fields such as orthopedics, urology, plastic surgery, cardiology, stomatology, oncology, and rehabilitation, treating millions of patients annually [7-9]. Concurrently, Chinese scholars in the field of shock wave therapy are continually innovating, integrating extracorporeal shock waves with techniques such as arthroscopy, stem cells, and nanomaterials to achieve synergistic therapeutic effects, resulting in favorable outcomes [10-12]. Each year, over 500 related research papers are published.
Further, elucidating the biological mechanisms of shock waves in clinical efficacy at the organizational, cellular, and molecular levels will continuously expand the application scope of shock waves. In response to the relative lack of high-level evidence for shock wave research, the China Shock Wave Medical Association is organizing multi-center, large-sample clinical studies; standardized training for practitioners and accreditation of treatment institutions have also been put on the agenda. It is believed that in the near future, China’s shock wave medicine will witness a richer array of research achievements, bringing blessings to more patients.

References:

1. Xing G. The past, present and future of shockwave medicine. Chin J Front Med Sci 2014;6:1-2.
2. Wang Y, Guo T, Cai HY, Ma TK, Tao SM, Sun S, et al. Cardiac shock wave therapy reduces angina and improves myocardial function in patients with refractory coronary artery disease. Clin Cardiol 2010;33:693-9.
3. Liu J, Zhou F, Li GY, Wang L, Li HX, Bai GY, et al. Evaluation of the effect of different doses of low energy shock wave therapy on the erectile function of streptozotocin (STZ)-induced diabetic rats. Int J Mol Sci 2013;14:10661-73.
4. Yan X, Yang G, Cheng L, Chen M, Cheng X, Chai Y, et al. Effect of extracorporeal shock wave therapy on diabetic chronic wound healing and its histological features. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2012;26:961-7.
5. Xing G, Huang C, Huang Z, Li Y, Li Z, Liu Y, et al. Professional Committee of Shock Wave Medicine of Chinese Research Hospital Association. Expert consensus of extracorporeal shock wave therapy for bone and muscle diseases. Chin J Front Med Sci 2014;6:170-7.
6. Xing G, Zhang H, Liu S, Zhao Z. Chinese guidelines for extracorporeal shockwave therapy for bone and muscle diseases (2019 Edition). Chin J Front Med Sci 2019;11:1-10.
7. Xu Y, Wu K, Liu Y, Geng H, Zhang H, Liu S, et al. The effect of extracorporeal shock wave therapy on the treatment of moderate to severe knee osteoarthritis and cartilage lesion. Medicine (Baltimore) 2019;98:e15523.
8. Li F, Zhen Z, Sun SJ, Jiang Y, Liang WH, Belau M, et al. Attenuation of myocardial dysfunction in hypertensive cardiomyopathy using non-R-wave-synchronized cardiac shock wave therapy. Int J Mol Sci 2022;23:13274.
9. Huang Q, Yan P, Xiong H, Shuai T, Liu J, Zhu L, et al. Extracorporeal shock wave therapy for treating foot ulcers in adults with type 1 and type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. Can J Diabetes 2020;44:196-204.e3.
10. Liang H, Chen K, Xie J, Yao L, Liu Y, Hu F, et al. A bone-penetrating precise controllable drug release system enables localized treatment of osteoporotic fracture prevention via modulating osteoblast-osteoclast communication. Small 2023;19:e2207195.
11. Bai X, Gao Y, Zhang M, Chang YN, Chen K, Li J, et al. Carboxylated gold nanoparticles inhibit bone erosion by disturbing the acidification of an osteoclast absorption microenvironment. Nanoscale 2020;12:3871-8.
12. Zeng L, Geng H, Gu W, Ma S, Qin Y, Xia S, et al. Au nanoparticles attenuate RANKL-induced osteoclastogenesis by suppressing pre-osteoclast fusion. J Nanosci Nanotechnol 2019;19:2166-73.

 

How to Cite this article: Liu S, Xing G | The History of Shock Wave Medicine Development in China. | Journal of Regenerative Science | Jul-Dec 2023; 3(2): 03-04.

[Full Text HTML] [Full Text PDF] 

Shock Wave Medicine: A Transformative Evolution in Modern Medicine

/0 Comments/in /by

Original Article | Vol 3 | Issue 2 |  July-December 2023 | page: 05-09 | Sunte Li, Xiaoyu Fan, Wei Sun

DOI: https://doi.org/10.13107/jrs.2023.v03.i02.89

Author: Sunte Li [1], Xiaoyu Fan [2], Wei Sun [3, 4]

[1] Friends Central School, Philadelphia, Pennsylvania, USA,
[2] Department of Surgery, Peking University People’s Hospital, Beijing, China,
[3] Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA,
[4] Department of Orthopedics, Shockwave Center, China-Japan Friendship Hospital, Chaoyang, Beijing, China.

Address of Correspondence
Dr. Wei Sun,
Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA/Department of Orthopedics, Shockwave Center, China-Japan Friendship Hospital, Chaoyang, Beijing, China.
E-mail: wei.sun@pennmedicine.upenn.edu

Abstract

Since its inception as extracorporeal shock wave lithotripsy in the 1980s, the landscape of medical treatment has been revolutionized by the evolution of shock wave therapy. Over four decades, this therapy, now known as extracorporeal shock wave therapy (ESWT), has emerged as a cornerstone in modern medicine, redefining treatment paradigms across various medical disciplines. Certainly, despite the promising outcomes witnessed in various medical conditions such as musculoskeletal disorders, wound healing, urinary calculi, and erectile dysfunction,
it is crucial to acknowledge that shock wave therapy’s relatively short clinical tenure necessitates a cautious approach. While its effectiveness has been repeatedly demonstrated, establishing industry-standard protocols through large-scale, prospective randomized controlled trials remains imperative to solidify its standing in medical practice.
The integration of Artificial Intelligence technology holds significant promise for the future of shockwave medicine, enabling personalized treatment plans, real-time feedback, and improved cost-effectiveness.
Keywords: Shock waves, ESWT, Shockwave

 

References:

1. Seoane LM, Salvador JB, Alba A, Fentes DA. Technological innovations in shock wave lithotripsy. Actas Urol Esp (Engl Ed) 2024; (48)-1:105-110. https://doi.org/10.1016/j.acuroe.2023.09.001
2. Moya D, Ramón S, Schaden W, Wang CJ, Guiloff L, Cheng JH. The role of extracorporeal shockwave treatment in musculoskeletal disorders. J Bone Joint Surg Am 2018;100:251-63.
3. Porst H. Review of the current status of low intensity extracorporeal shockwave therapy (Li-ESWT) in erectile dysfunction (ED), Peyronie’s disease (PD), and sexual rehabilitation after radical prostatectomy with special focus on technical aspects of the different marketed ESWT devices including personal experiences in 350 patients. Sex Med Rev 2021;9:93-122.
4. Van der Worp H, Van den Akker-Scheek I, Van Schie H, Zwerver J. ESWT for tendinopathy: Technology and clinical implications. Knee Surg Sports Traumatol Arthrosc 2013;21:1451-8.
5. Schroeder AN, Tenforde AS, Jelsing EJ. Extracorporeal shockwave therapy in the management of sports medicine injuries. Curr Sports Med Rep 2021;20:298-305.
6. Wang H, Shi Y. Extracorporeal shock wave treatment for post-surgical fracture nonunion: Insight into its mechanism, efficacy, safety and prognostic factors (Review). Exp Ther Med 2023;26:332.
7. Simplicio CL, Purita J, Murrell W, Santos GS, Dos Santos RG, Lana JF. Extracorporeal shock wave therapy mechanisms in musculoskeletal regenerative medicine. J Clin Orthop Trauma 2020;11:S309-18.
8. Wigley CH, Janssen TJ, Mosahebi A. Shock wave therapy in plastic surgery: A review of the current indications. Aesthet Surg J 2023;43:370-86.
9. Kuo YR, Wang CT, Wang FS, Chiang YC, Wang CJ. Extracorporeal shock-wave therapy enhanced wound healing via increasing topical blood perfusion and tissue regeneration in a rat model of STZ-induced diabetes. Wound Repair Regen 2009;17:522-30.
10. Lee SY, Joo SY, Cho YS, Hur GY, Seo CH. Effect of extracorporeal shock wave therapy for burn scar regeneration: A prospective, randomized, double-blinded study. Burns 2021;47:821-7.
11. Yao H, Wang X, Liu H, Sun F, Tang G, Bao X et al. Systematic Review and Meta-Analysis of 16 Randomized Controlled Trials of Clinical Outcomes of Low-Intensity Extracorporeal Shock Wave Therapy in Treating Erectile Dysfunction. Am J Mens Health. 2022 Mar-Apr;16(2):15579883221087532. doi: 10.1177/15579883221087532. PMID: 35319291; PMCID: PMC8949743.
12. Dong L, Chang D, Zhang X, Li J, Yang F, Tan K, et al. Effect of low-intensity extracorporeal shock wave on the treatment of erectile dysfunction: A systematic review and meta-analysis. Am J Mens Health 2019;13:2. Published online. Open access: https://journals.sagepub.com/action/showCitFormats?doi=10.1177%2F1557988319846749&mobileUi=0
13. Wu WL, Bamodu OA, Wang YH, Hu SW, Tzou KY, Yeh CT, et al. Extracorporeal shockwave therapy (ESWT) alleviates pain, enhances erectile function and improves quality of Life in patients with chronic prostatitis/chronic pelvic pain syndrome. J Clin Med 2021;3602.
14. Radu CA, Kiefer J, Horn D, Rebel M, Koellensperger E, Gebhard MM, et al. Shock wave treatment in composite tissue allotransplantation. Eplasty 2011;11:e37.
15. Li HX, Zhang ZC, Peng J. Low-intensity extracorporeal shock wave therapy promotes recovery of sciatic nerve injury and the role of mechanical sensitive YAP/TAZ signaling pathway for nerve regeneration. Chin Med J (Engl) 2021;134:2710-20.
16. Mittermayr R, Hartinger J, Antonic V, Meinl A, Pfeifer S, Stojadinovic A, et al. Extracorporeal shock wave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis. Ann Surg 2011;253:1024-32.
17. Yamaya S, Ozawa H, Kanno H, Kishimoto KN, Sekiguchi A, Tateda S, et al. Low-energy extracorporeal shock wave therapy promotes vascular endothelial growth factor expression and improves locomotor recovery after spinal cord injury. J Neurosurg 2014;121:1514-25.
18. López-Marín LM, Rivera AL, Fernández F, Loske AM. Shock wave-induced permeabilization of mammalian cells. Phys Life Rev 2018;26-27:1-38.
19. Yeh KH, Sheu JJ, Lin YC, Sun CK, Chang LT, Kao YH, et al. Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats. Crit Care Med 2012;40:169-77.
20. Reichenberger MA, Heimer S, Schaefer A, Lass U, Gebhard MM, Germann G, et al. Extracorporeal shock wave treatment protects skin flaps against ischemia-reperfusion injury. Injury 2012;43:374-80.
21. Sung PH, Fu M, Chiang HJ, Huang CR, Chu CH, Lee MS, et al. Reduced effects of cardiac extracorporeal shock wave therapy on angiogenesis and myocardial function recovery in patients with end-stage coronary artery and renal diseases. Biomed J 2021;44:S201-9.
22. Oktaş B, Orhan Z, Erbil B, Değirmenci E, Ustündağ N. Effect of extracorporeal shock wave therapy on fracture healing in rat femural fractures with intact and excised periosteum. Eklem Hastalik Cerrahisi 2014;25:158-62.
23. Qiao HY, Xin L, Wu SL. Analgesic effect of extracorporeal shock-wave therapy for frozen shoulder: A randomized controlled trial protocol. Medicine (Baltimore) 2020;99:e21399.
24. Fiani B, Davati C, Griepp DW, Lee J, Pennington E, Moawad CM. Enhanced spinal therapy: Extracorporeal shock wave therapy for the spine. Cureus 2020;12:e11200.
25. Özkan E, Şenel E, Bereket MC, Önger ME. The effect of shock waves on mineralization and regeneration of distraction zone in osteoporotic rabbits. Ann Med 2023;55:1346-54.
26. Shi L, Gao F, Sun W, Wang B, Guo W, Cheng L, et al. Short-term effects of extracorporeal shock wave therapy on bone mineral density in postmenopausal osteoporotic patients. Osteoporos Int 2017;28:2945-53.
27. Hao L, Liu Y, Wang T, Guo HL, Wang D, Bi YW, et al. Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis. J Gastroenterol Hepatol 2019;34:466-73.
28. Klang E, Portugez S, Gross R, Lerner KR, Brenner A, Gilboa M, et al. Advantages and pitfalls in utilizing artificial intelligence for crafting medical examinations: A medical education pilot study with GPT-4. BMC Med Educ 2023;23:772.
29. Wójcik S, Rulkiewicz A, Pruszczyk P, Lisik W, Poboży M, Domienik-Karłowicz J. Beyond ChatGPT: What does GPT-4 add to healthcare? The dawn of a new era. Cardiol J 2023;30:1018-25.
30. Mun C, Ha H, Lee O, Cheon M. Enhancing AI-CDSS with U-AnoGAN: Tackling data imbalance. Comput Methods Programs Biomed 2023;244:107954.
31. Palavicini G. Intelligent health: Progress and benefit of artificial intelligence in sensing-based monitoring and disease diagnosis. Sensors (Basel) 2023;23:9053.

How to Cite this article: Li S, Fan X, Sun W. | Shock Wave Medicine: A Transformative Evolution in Modern Medicine. | Journal of Regenerative Science | Jul-Dec 2023; 3(2): 05-09.

 

[Full Text HTML] [Full Text PDF] 

Extracorporeal Shockwave Therapy in Osteonecrosis of the Femoral Head: Where Do We Stand?

/0 Comments/in /by

Original Article | Vol 3 | Issue 2 |  July-December 2023 | page: 10-13 | Tianyang Liu, Fuqiang Gao, Wei Sun

DOI: https://doi.org/10.13107/jrs.2023.v03.i02.91

Author: Tianyang Liu [1], Fuqiang Gao [2], Wei Sun [2, 3]

[1] Capital Medical University China-Japanese Friendship Clinical Medical Research Institute, Beijing, China,
[2] Department of Orthopedics, Shockwave Center, China-Japan Friendship Hospital, Chaoyang, Beijing, China,
[3] Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Address of Correspondence
Dr. Wei Sun,
Department of Orthopedics, Shockwave Center, China-Japan Friendship Hospital, Chaoyang, Beijing,
China/Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
E-mail: wei.sun@pennmedicine.upenn.edu

Abstract

Osteonecrosis of the femoral head (ONFH) is a progressive disease characterized by ischemic lesions and structural damage in the head of the femur caused by insufficient blood supply due to multiple etiologies. As a safe, effective, non-invasive, and low-cost treatment strategy, Extracorporeal Shockwave Treatment (ESWT) is now widely applied in musculoskeletal disorders such as delayed bone healing, bone marrow edema (BME), knee osteoarthritis, and certain types of avascular bone necrosis. ESWT may promote vascularization and osteogenesis through a cascade reaction stimulated by the transformation of physical energy, promoting tissue regeneration, and repair. ESWT is recommended in treating early-stage ONFH.
Keywords: Shock waves; ESWT, Femoral head osteonecrosis

References:

1. Mont MA, Salem HS, Piuzzi NS, Goodman SB, Jones LC. Nontraumatic osteonecrosis of the femoral head: Where do we stand today? A 5-year update. J Bone Joint Surg Am 2020;102:1084-99.
2. Zhang Q, Liu L, Sun W, Gao F, Cheng L, Li Z. Extracorporeal shockwave therapy in osteonecrosis of femoral head: A systematic review of now available clinical evidences. Medicine (Baltimore) 2017;96:e5897.
3. Haupt G. Use of extracorporeal shock waves in the treatment of pseudarthrosis, tendinopathy and other orthopedic diseases. J Urol 1997;158:4-11.
4. Auersperg V, Trieb K. Extracorporeal shock wave therapy: An update. EFORT Open Rev 2020;5:584-92.
5. Moya D, Ramón S, Schaden W, Wang CJ, Guiloff L, Cheng JH. The role of extracorporeal shockwave treatment in musculoskeletal disorders. J Bone Joint Surg Am 2018;100:251-63.
6. Wang QW, Zhang QY, Gao FQ, Sun W. Focused extra-corporeal shockwave treatment during early stage of osteonecrosis of femoral head. Chin Med J (Engl) 2019;132:1867-9.
7. Cheng JH, Wang CJ. Biological mechanism of shockwave in bone. Int J Surg 2015;24:143-6.
8. Wu X, Wang Y, Fan X, Xu X, Sun W. Extracorporeal shockwave relieves endothelial injury and dysfunction in steroid-induced osteonecrosis of the femoral head via miR-135b targeting FOXO1: In vitro and in vivo studies. Aging (Albany NY) 2022;14:410-29.
9. Li B, Wang R, Huang X, Ou Y, Jia Z, Lin S, et al. Extracorporeal shock wave therapy promotes osteogenic differentiation in a rabbit osteoporosis model. Front Endocrinol (Lausanne) 2021;12:627718.
10. Hsu SL, Jhan SW, Hsu CC, Wu YN, Wu KL, Kuo CA, et al. Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral head. Biomed J 2022;46:100571.
11. Sun W, Li Z. Extracorporeal shockwave therapy for osteonecrosis of femoral head: Traps and challenges. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019;33:659-61.
12. Ludwig J, Lauber S, Lauber HJ, Dreisilker U, Raedel R, Hotzinger H. High-energy shock wave treatment of femoral head necrosis in adults. Clin Orthop Relat Res 2001:119-26.
13. Qu RD, Sun W. Interpretation of international society for medical shockwave treatment consensus-2021 in diagnosis and treatment of musculoskeletal diseases. Chin J Gen Pract 2022;21:826-30.
14. Gao F, Sun W, Li Z, Guo W, Wang W, Cheng L, et al. High-energy extracorporeal shock wave for early stage osteonecrosis of the femoral head: A single-center case series. Evid Based Complement Alternat Med 2015;2015:468090.
15. Sun W, Gao F, Guo W, Wang B, Li Z, Cheng L, et al. Focused extracorporeal shock wave for osteonecrosis of the femoral head with leukemia after allo-HSCT: A case series. Bone Marrow Transplant 2016;51:1507-9.
16. Yang X, Shi L, Zhang T, Gao F, Sun W, Wang P, et al. High-energy focused extracorporeal shock wave prevents the occurrence of glucocorticoid-induced osteonecrosis of the femoral head: A prospective randomized controlled trial. J Orthop Translat 2022;36:145-51.
17. Xie K, Mao Y, Qu X, Dai K, Jia Q, Zhu Z, et al. High-energy extracorporeal shock wave therapy for nontraumatic osteonecrosis of the femoral head. J Orthop Surg Res 2018;13:25.
18. Zhao W, Gao Y, Zhang S, Liu Z, He L, Zhang D, et al. Extracorporeal shock wave therapy for bone marrow edema syndrome in patients with osteonecrosis of the femoral head: A retrospective cohort study. J Orthop Surg Res 2021;16:21.
19. Alkhawashki HM, Al-Boukai AA, Al-Harbi MS, Al-Rumaih MH, Al-Khawashki MH. The use of extracorporeal shock wave therapy (ESWT) in treating osteonecrosis of the femoral head (AVNFH): A retrospective study. Int Orthop 2023;47:2953-60.
20. Abbas A, Khan Z, Veqar Z. Dose dependent effects of extracorporeal shockwave therapy on pain and function in osteonecrosis of femoral head: A systematic review. J Clin Orthop Trauma 2023;45:102275.
21. Császár NB, Angstman NB, Milz S, Sprecher CM, Kobel P, Farhat M, et al. Radial shock wave devices generate cavitation. PLoS One 2015;10:e0140541.
22. Moya D, Sun W, Simplicio C, Guiloff L, Kwangsun P, Giorno A, et al. Scientific evidence of shock waves in orthopedics and traumatology: It is time to set the record straight. J Regen Sci 2023;3:1-6.

How to Cite this article: Liu T, Gao F, Sun W Extracorporeal | Shockwave Therapy in Osteonecrosis of the Femoral Head: Where Do We Stand? | Journal of Regenerative Science | Jul-Dec 2023; 3(2): 10-13.

 

 

 

[Full Text HTML] [Full Text PDF] 

Chinese Expert Consensus on Clinical Diagnosis and Treatment Technique of Osteonecrosis of the Femoral Head (2023)

/0 Comments/in /by

Original Article | Vol 3 | Issue 2 |  July-December 2023 | page: 14-21 | Wei Sun, Fuqiang Gao, Zirong Li, Xin Xu, Jike Lu

DOI: https://doi.org/10.13107/jrs.2023.v03.i02.93

Author: Wei Sun [1, 2], Fuqiang Gao [1], Zirong Li [1], Xin Xu [1], Jike Lu [1]

[1] Centre for Osteonecrosis and Joint-Preserving and Reconstruction, Department of Orthopedics, China-Japan Friendship Hospital, Beijing, 100029, China.
[2] Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Address of Correspondence
Dr. Wei Sun,
Centre for Osteonecrosis and Joint-Preserving and Reconstruction, Department of Orthopedics, China-Japan Friendship Hospital, Beijing, 100029, China. /Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia,
Pennsylvania, USA.
E-mail: lizirongon@163.com

Abstract

Osteonecrosis of the femoral head (ONFH) is a common and refractory disease. Although the exact pathophysiological mechanism is not fully understood, it is believed to be closely related to the interruption of intra-bone circulation and eventual bone tissue death. The prevention and treatment of ONFH are always a great challenge for orthopedists. The diagnostic level of ONFH has been continuously improved with the development of imaging techniques such as magnetic resource imaging and the in-depth understanding of the disease in recent years. There are many treatment methods for ONFH, which are generally considered individually and comprehensively according to factors such as the patient’s age, osteonecrosis stage, classification, and compliance with joint-sparing treatment. There is currently no unified standard. ONFH staging and classification play an important reference value for doctors to choose treatment options. In recent years, based on the characteristics of ONFH in Chinese people, the academic community has proposed Chinese staging and China-Japan Friendship Hospital classification. The consensus also introduces them together with the international ARCO staging to provide guidance for individualized treatment of ONFH. To further standardize the diagnosis of ONFH and expand the treatment of ONFH, the Association Related to Osseous Microcirculation Chinese Microcirculation Society organized domestic experts in the field of ONFH to jointly formulate the expert consensus, to provide reference for the standardized diagnosis of ONFH and the selection of individualized diagnosis and treatment techniques.
Keywords: Expert consensus, Osteonecrosis of the femoral head, Diagnosis, Treatment technique

References:

1. Mont MA, Salem HS, Piuzzi NS, Goodman SB, Jones LC. Nontraumatic osteonecrosis of the femoral head: Where do we stand today? A 5-year update. J Bone Joint Surg Am 2020;102:1084-99.
2. Zhang Q, Liu L, Sun W, Gao F, Cheng L, Li Z. Extracorporeal shockwave therapy in osteonecrosis of femoral head: A systematic review of now available clinical evidences. Medicine (Baltimore) 2017;96:e5897.
3. Haupt G. Use of extracorporeal shock waves in the treatment of pseudarthrosis, tendinopathy and other orthopedic diseases. J Urol 1997;158:4-11.
4. Auersperg V, Trieb K. Extracorporeal shock wave therapy: An update. EFORT Open Rev 2020;5:584-92.
5. Moya D, Ramón S, Schaden W, Wang CJ, Guiloff L, Cheng JH. The role of extracorporeal shockwave treatment in musculoskeletal disorders. J Bone Joint Surg Am 2018;100:251-63.
6. Wang QW, Zhang QY, Gao FQ, Sun W. Focused extra-corporeal shockwave treatment during early stage of osteonecrosis of femoral head. Chin Med J (Engl) 2019;132:1867-9.
7. Cheng JH, Wang CJ. Biological mechanism of shockwave in bone. Int J Surg 2015;24:143-6.
8. Wu X, Wang Y, Fan X, Xu X, Sun W. Extracorporeal shockwave relieves endothelial injury and dysfunction in steroid-induced osteonecrosis of the femoral head via miR-135b targeting FOXO1: In vitro and in vivo studies. Aging (Albany NY) 2022;14:410-29.
9. Li B, Wang R, Huang X, Ou Y, Jia Z, Lin S, et al. Extracorporeal shock wave therapy promotes osteogenic differentiation in a rabbit osteoporosis model. Front Endocrinol (Lausanne) 2021;12:627718.
10. Hsu SL, Jhan SW, Hsu CC, Wu YN, Wu KL, Kuo CA, et al. Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral head. Biomed J 2022;46:100571.
11. Sun W, Li Z. Extracorporeal shockwave therapy for osteonecrosis of femoral head: Traps and challenges. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019;33:659-61.
12. Ludwig J, Lauber S, Lauber HJ, Dreisilker U, Raedel R, Hotzinger H. High-energy shock wave treatment of femoral head necrosis in adults. Clin Orthop Relat Res 2001:119-26.
13. Qu RD, Sun W. Interpretation of international society for medical shockwave treatment consensus-2021 in diagnosis and treatment of musculoskeletal diseases. Chin J Gen Pract 2022;21:826-30.
14. Gao F, Sun W, Li Z, Guo W, Wang W, Cheng L, et al. High-energy extracorporeal shock wave for early stage osteonecrosis of the femoral head: A single-center case series. Evid Based Complement Alternat Med 2015;2015:468090.
15. Sun W, Gao F, Guo W, Wang B, Li Z, Cheng L, et al. Focused extracorporeal shock wave for osteonecrosis of the femoral head with leukemia after allo-HSCT: A case series. Bone Marrow Transplant 2016;51:1507-9.
16. Yang X, Shi L, Zhang T, Gao F, Sun W, Wang P, et al. High-energy focused extracorporeal shock wave prevents the occurrence of glucocorticoid-induced osteonecrosis of the femoral head: A prospective randomized controlled trial. J Orthop Translat 2022;36:145-51.
17. Xie K, Mao Y, Qu X, Dai K, Jia Q, Zhu Z, et al. High-energy extracorporeal shock wave therapy for nontraumatic osteonecrosis of the femoral head. J Orthop Surg Res 2018;13:25.
18. Zhao W, Gao Y, Zhang S, Liu Z, He L, Zhang D, et al. Extracorporeal shock wave therapy for bone marrow edema syndrome in patients with osteonecrosis of the femoral head: A retrospective cohort study. J Orthop Surg Res 2021;16:21.
19. Alkhawashki HM, Al-Boukai AA, Al-Harbi MS, Al-Rumaih MH, Al-Khawashki MH. The use of extracorporeal shock wave therapy (ESWT) in treating osteonecrosis of the femoral head (AVNFH): A retrospective study. Int Orthop 2023;47:2953-60.
20. Abbas A, Khan Z, Veqar Z. Dose dependent effects of extracorporeal shockwave therapy on pain and function in osteonecrosis of femoral head: A systematic review. J Clin Orthop Trauma 2023;45:102275.
21. Császár NB, Angstman NB, Milz S, Sprecher CM, Kobel P, Farhat M, et al. Radial shock wave devices generate cavitation. PLoS One 2015;10:e0140541.
22. Moya D, Sun W, Simplicio C, Guiloff L, Kwangsun P, Giorno A, et al. Scientific evidence of shock waves in orthopedics and traumatology: It is time to set the record straight. J Regen Sci 2023;3:1-6.

How to Cite this article: Sun W, Gao F, Li Z, Xu X | Chinese Expert Consensus on Clinical Diagnosis and Treatment Technique of Osteonecrosis of the Femoral Head (2023). | Journal of Regenerative Science | Jul-Dec 2023; 3(2): 14-21.

Full Text HTML] [Full Text PDF] 

Chinese expert consensus on clinical drug prevention and treatment of osteonecrosis of the femoral head（2023)

/0 Comments/in /by

Original Article | Vol 3 | Issue 2 |  July-December 2023 | page: 22-28 | Wei Sun , Fuqiang Gao , Zirong Li , Xu Yang , Jike Lu

DOI: https://doi.org/10.13107/jrs.2023.v03.i02.95

Author: Wei Sun , Fuqiang Gao , Zirong Li , Xu Yang , Jike Lu

[1] Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Department of Orthopedics, China-Japan Friendship Hospital, Beijing 100029, China.
[2] Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Address of Correspondence
Dr. Wei Sun,
Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Department
of Orthopedics, China-Japan Friendship Hospital, Beijing 100029, China.
E-mail: wei.sun@pennmedicine.upenn.edu

Abstract

The in-depth understanding of osteonecrosis of the femoral head (ONFH), has lead more and more patients to seek for medical treatment in the early stage of the disease. Surgical treatment of femoral head necrosis alone is no longer sufficient for the current patients’ demand. The rational and effective use of drugs to strengthen the prevention and early treatment of femoral head necrosis delaying the progression of the disease, is becoming more and more important. This article combines the latest expert consensus and evidence-based medical research on the principles of ONFH diagnosis and treatment according to Chinese and Western medicine and is organized by Chinese experts from the Association Related to Osseous Circulation and the Chinese Microcirculation Society (CSM-ARCO). This consensus was formulated with focus on drug types, characteristics, and safety. Rationality and consideration of basic principles of drug use will provide safe, reasonable, standardized, and effective drug use in medical institutions at all levels. This consensus is only an expert guideline based on literature and clinical experience, not a requirement for mandatory implementation. The clinical practice can be tailored to the actual local conditions to develop appropriate prevention and treatment measures for patients.
Keywords: Osteonecrosis of the femoral head; Expert consensus; Drug prevention and treatment

References:

[1] Sun W. The etiology, pathology and pathogenesis of osteonecrosis of the femoral head. Chinese Journal of General Practitioners, 2006, (02): 75-7. In Chinese.
[2] Cui L., Zhuang Q., Lin J., et al. Multicentric epidemiologic study on six thousand three hundred and ninety five cases of femoral head osteonecrosis in China. Int Orthop, 2016, 40(2): 267-76.
[3] van den Heuvel-Eibrink M. M., Pieters R. Steroids and risk of osteonecrosis in ALL: take a break. The Lancet Oncology, 2012, 13(9): 855-7.
[4] Li ZR. Clinical diagnosis and treatment of osteonecrosis of the femoral head (2015 edition). Chinese Journal of Joint Surgery (Electronic Edition), 2015, 9(01): 133-8. In Chinese.
[5] Chinese guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2020). Chinese Journal of Orthopaedics, 2020, 40(20): 1365-76. In Chinese.
[6] Wei QS, Yang F, Chen XJ, et al. Microarchitecture features and pathology of necrotic region in patients with steroid-induced and alcohol-induced osteonecrosis of femoral head. Chinese Journal of Rehabilitation and Reconstructive Surgery, 2018, 32(07): 866- 72. In Chinese.
[7] Expert consensus on the criteria for the diagnosis and treatment of adult femoral head necrosis (2012). Chinese Journal of Bone and Joint Surgery, 2012, 5(02): 188-95. In Chinese.
[8] Chinese guideline for the diagnosis and treatment of osteonecrosis of the femoral head (2016). Chinese Journal of Orthopaedics, 2016, 36(15): 945-54. In Chinese.
[9] Yoon B. H., Mont M. A., Koo K. H., et al. The 2019 Revised Version of Association Research Circulation Osseous Staging System of Osteonecrosis of the Femoral Head. J Arthroplasty, 2020, 35(4): 933-40.
[10] Glueck C. J., Freiberg R. A., Wang P. Treatment of Osteonecrosis of the Hip and Knee with Enoxaparin. Osteonecrosis. 2014: 241-7.
[11] Guo P., Gao F., Wang Y., et al. The use of anticoagulants for prevention and treatment of osteonecrosis of the femoral head: A systematic review. Medicine (Baltimore), 2017, 96(16): e6646.
[12] Liu B. Y., Yang L., Wang B. J., et al. Prevention for glucocorticoid-induced osteonecrosis of femoral head: a long-term clinical follow-up trail. Zhonghua yi xue za zhi, 2017, 97(41): 3213-8. In Chinese.
[13] Albers A., Carli A., Routy B., et al. Treatment with acetylsalicylic acid prevents short to mid-term radiographic progression of nontraumatic osteonecrosis of the femoral head: a pilot study. Canadian journal of surgery Journal canadien de chirurgie, 2015, 58(3): 198-205.
[14] Cao H., Guan H., Lai Y., et al. Review of various treatment options and potential therapies for osteonecrosis of the femoral head. Journal of orthopaedic translation, 2016, 4: 57-70.
[15] Mont M. A., Salem H. S., Piuzzi N. S., et al. Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today?: A 5-Year Update. The Journal of bone and joint surgery American volume, 2020, 102(12): 1084-99.
[16] Guo P., Gao F., Wang Y., et al. The use of anticoagulants for prevention and treatment of osteonecrosis of the femoral head: A systematic review. 2017, 96(16): e6646.
[17] Albers A., Carli A., Routy B., et al. Treatment with acetylsalicylic acid prevents short to mid-term radiographic progression of nontraumatic osteonecrosis of the femoral head: a pilot study. 2015, 58(3): 198-205.
[18] Wang W., Zhang N., Guo W., et al. Combined pharmacotherapy for osteonecrosis of the femoral head after severe acute respiratory syndrome and interstitial pneumonia: two and a half to fourteen year follow-up. 2018, 42(7): 1551-6.
[19] Li D., Yang Z., Wei Z., et al. Efficacy of bisphosphonates in the treatment of femoral head osteonecrosis: A PRISMA-compliant meta-analysis of animal studies and clinical trials. 2018, 8(1): 1450.
[20] Hong Y. C., Luo R. B., Lin T., et al. Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis. Biomed Res Int, 2014, 2014: 716538.
[21] Ramachandran M., Ward K., Brown R. R., et al. Intravenous bisphosphonate therapy for traumatic osteonecrosis of the femoral head in adolescents. The Journal of bone and joint surgery American volume, 2007, 89(8): 1727-34.
[22] Yuan H. F., Guo C. A., Yan Z. Q. The use of bisphosphonate in the treatment of osteonecrosis of the femoral head: a meta-analysis of randomized control trials. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016, 27(1): 295-9.
[23] Tong PJ, Xiao LW, Ji WF, et al. Research on the role of metabolism of fatty substance and osteoclast activity during the development of steroid-induced necrosis of femoral head. China Journal of Orthopaedics and Traumatology, 2009, 22 (02): 110-3. In Chinese.
[24] Pritchett J. W. Statin therapy decreases the risk of osteonecrosis in patients receiving steroids. Clinical orthopaedics and related research, 2001, (386): 173-8.
[25] Kandil A., Cui Q. Lipid-lowering agents and their effects on osteonecrosis: Pros and cons. Osteonecrosis. 2014: 255-9.
[26] Li Z. R., Cheng L. M., Wang K. Z., et al. Herbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral head-A first multicentre, randomised, double-blind, placebo-controlled clinical trial. Journal of orthopaedic translation, 2018, 12: 36-44.
[27] Huang Z., Fu F., Ye H., et al. Chinese herbal Huo-Gu formula for the treatment of steroid-associated osteonecrosis of femoral head: A 14-year follow-up of convalescent SARS patients. Journal of orthopaedic translation, 2020, 23: 122-31.
[28] Leucht P., Goodman S. B. Is there a role for BMPs in the treatment of osteonecrosis?. Osteonecrosis. 2014: 261-4.
[29] Sun W., Li Z., Gao F., et al. Recombinant human bone morphogenetic protein-2 in debridement and impacted bone graft for the treatment of femoral head osteonecrosis. 2014, 9(6): e100424.
[30] Vandermeer J., Kamiya N., Aya-ay J., et al. Local administration of ibandronate and bone morphogenetic protein-2 after ischemic osteonecrosis of the immature femoral head: a combined therapy that stimulates bone formation and decreases femoral head deformity. 2011, 93(10): 905-13.
[31] Drescher W., Knobe M., Wagner W., et al. New therapies of bone necrosis. Osteonecrosis. 2014: 273-5.
[32] Xu Y., Jiang Y., Xia C., et al. Stem cell therapy for osteonecrosis of femoral head: Opportunities and challenges. 2020, 15: 295-304.
[33] Lee H. S., Huang G. T., Chiang H., et al. Multipotential mesenchymal stem cells from femoral bone marrow near the site of osteonecrosis. Stem cells (Dayton, Ohio), 2003, 21(2): 190-9.
[34] Li C., Li G., Liu M., et al. Paracrine effect of inflammatory cytokine-activated bone marrow mesenchymal stem cells and its role in osteoblast function. 2016, 121(2): 213-9.
[35] Haumer A., Bourgine P., Occhetta P., et al. Delivery of cellular factors to regulate bone healing. 2018, 129: 285-94.
[36] Mao L., Jiang P., Lei X., et al. Efficacy and safety of stem cell therapy for the early-stage osteonecrosis of femoral head: a systematic review and meta-analysis of randomized controlled trials. Stem Cell Res Ther, 2020, 11(1): 445.
[37] Han J., Gao F., Li Y., et al. The Use of Platelet-Rich Plasma for the Treatment of Osteonecrosis of the Femoral Head: A Systematic Review. Biomed Res Int, 2020, 2020: 2642439.
[38] Liu GH, Ji WB, Liu JT, et al. Clinical observation of Yishen Huoxue decoction (YSHXD) for the treatment of non-traumatic osteonecrosis of femoral head at early and middle stage. China Journal of Orthopaedics and Traumatology, 2019, 32 (11): 1003-7. In Chinese.
[39] Sung P., Yang Y., Chiang H., et al. Cardiovascular and Cerebrovascular Events Are Associated With Nontraumatic Osteonecrosis of the Femoral Head. 2018, 476(4): 865-74.
[40] Emkey R., Delmas P. D., Bolognese M., et al. Efficacy and tolerability of once-monthly oral ibandronate (150 mg) and once-weekly oral alendronate (70 mg): additional results from the Monthly Oral Therapy With Ibandronate For Osteoporosis Intervention (MOTION) study. Clin Ther, 2009, 31(4): 751-61.
[41] Teng J, Wang D, Xu X, et al. Surveying the status of older patients’ multiple-drug- using behavior and studying on the clinical strategies of co-morbidity management. The Chinese Health Service Management, 2015, 32(09): 695-7. In Chinese.
[42] Sodhi N., Acuna A., Etcheson J., et al. Management of osteonecrosis of the femoral head. 2020: 122-8.

How to Cite this article: Sun W, Gao F, Li Z, Yang X, Lu J | Chinese expert consensus on clinical drug prevention and treatment of osteonecrosis of the femoral head（2023). | Journal of Regenerative Science | Jul-Dec 2023; 3(2): 22-28.

 

[Full Text HTML] [Full Text PDF]