Posts

Visualization Analysis of Research Progress and Trends in Coronary Heart Disease Cardiac Rehabilitation Based on Bibliometrics

/0 Comments/in /by

Research Article | Vol 6 | Issue 1 |  January-June 2026 | page: 14-21 | Na Chen

DOI: https://doi.org/10.13107/jrs.2026.v06.i01.193

Open Access License: CC BY-NC 4.0

Copyright Statement: Copyright © 2026; The Author(s).

Submitted Date: 25 Mar 2026, Review Date: 02 April 2026, Accepted Date: May 2026 & Published: 30 June 2026

Author: Na Chen [1]

[1] Department of Internal Medicine, Peking University Hospital, Beijing, China
.

Address of Correspondence
Dr. Na Chen,
Department of Internal Medicine, Peking University Hospital, Beijing, China.
E-mail: CN09558@pku.edu.cn

Abstract

Purpose: Coronary heart disease (CHD) remains a leading cause of global mortality, and cardiac rehabilitation (CR) is a core component of secondary prevention to improve patient outcomes. This study employed bibliometric methods to visually analyze the research status, hotspots, and evolutionary trends in CHD CR over the past 26 years, providing references for future research directions.
Methods: Using the Web of Science Core Collection as the data source, we searched for literature on CHD CR with the query: TS = ([“Coronary Heart Disease” OR “CHD”] AND (“Cardiac Rehabilitation” OR “CR”]) covering the period from 1999 to August 2025. After excluding non-English studies, conference proceedings, retracted publications, and book chapters, 1,885 valid articles were included. Bibliometric analysis was performed using VOSviewer and CiteSpace to explore publication trends, contributions of countries, institutions, authors, and journals, as well as keyword co-occurrence, clustering, and burst dynamics.
Results: A total of 1,885 articles were published by 8,492 authors from 2,767 institutions across 82 countries, in 531 journals, with 53,513 citations from 11,695 sources. The annual publication volume showed a steady upward trend, increasing from ≤60 articles in the early 2000s to over 100 articles annually after 2017. The top three countries in terms of publication quantity were the USA (484 articles), the United Kingdom (293 articles), and China (277 articles); Canada had the highest average citation frequency (72.1 citations/article). The most productive institutions were the University of Sydney (62 articles) and the University of Queensland (45 articles). The leading authors were Lavie, Carl J. (36 articles) and Taylor, Rod S. (27 articles, with an average citation frequency of 173.9). The journal with the most publications was Journal of Cardiopulmonary Rehabilitation and Prevention (113 articles), while HEART had the highest average citation frequency (82.1). High-frequency keywords included “coronary heart disease” (1,208 times), “cardiac rehabilitation” (1,106 times), and “secondary prevention” (443 times); keywords with high centrality were “coronary heart disease” (0.13) and “quality of life” (0.10). Keyword clustering identified six research hotspots: myocardial infarction, congenital heart disease, physical activity, risk factors, health, and quality of life. Recent burst keywords (2020–2025) included “percutaneous coronary intervention”, “systematic review”, “mobile health”, and “European Society”.
Conclusion: CHD CR research has shown continuous growth, with the USA and European countries leading in academic influence. Current research focuses on exercise-based rehabilitation, secondary prevention, and quality of life improvement; future directions may emphasize personalized rehabilitation programs, digital health applications, and long-term efficacy of rehabilitation after percutaneous coronary intervention.
Keywords: Coronary heart disease, Cardiac rehabilitation, Bibliometrics, VOSviewer, CiteSpace

References

1. World Health Organization. Cardiovascular Diseases (CVDs); 2025. Available from: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) [last accessed on July 22, 2025].
2. Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke statistics-2019 update: A report from the American heart association. Circulation 2019;139:e56-528.
3. Maglietta G, Ardissino M, Malagoli Tagliazucchi G, Disisto C, Merlini PA, Crocamo A, et al. Long-term outcomes after early-onset myocardial infarction. J Am Coll Cardiol 2019;74:2113-5.
4. Dibben GO, Faulkner J, Oldridge N, Rees K, Thompson DR, Zwisler AD, et al. Exercise-based cardiac rehabilitation for coronary heart disease: A meta-analysis. Eur Heart J 2023;44:452-69.
5. Shi Y, Xu H, Dong J. Exercise-based cardiac rehabilitation for patients undergoing coronary artery operation: A systematic review and meta-analysis based on current randomized controlled trials. Int J Surg 2025;111:2708-21.
6. Piepoli MF, Corrà U, Adamopoulos S, Benzer W, Bjarnason-Wehrens B, Cupples M, et al. Secondary prevention in the clinical management of patients with cardiovascular diseases. Core components, standards and outcome measures for referral and delivery: A policy statement from the cardiac rehabilitation section of the European Association for cardiovascular prevention & rehabilitation. Endorsed by the committee for practice guidelines of the European Society of Cardiology. Eur J Prev Cardiol 2014;21:664-81.
7. Balady GJ, Ades PA, Bittner VA, Franklin BA, Gordon NF, Thomas RJ, et al. Referral, enrollment, and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond: A presidential advisory from the American Heart Association. Circulation 2011;124:2951-60.
8. Takroni MA, Thow M, Ellis B, Seenan C. Home-based versus outpatient-based cardiac rehabilitation post-coronary artery bypass graft surgery: A randomized controlled trial. J Cardiovasc Nurs 2022;37:274-80.
9. Luijk A, Mortensen SR, Hamborg TG, Zangger G, Ahler JR, Christensen J, et al. The effectiveness of digital health interventions for the maintenance of physical activity following cardiac rehabilitation: A systematic review and meta-analysis. Digit Health 2024;10:20552076241286641.
10. Ninkov A, Frank JR, Maggio LA. Bibliometrics: Methods for studying academic publishing. Perspect Med Educ 2022;11:173-6.
11. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 2010;84:523-38.
12. Zhang J, Zhang J, Jin J, Jiang X, Yang L, Fan S, et al. Artificial intelligence applied in cardiovascular disease: A bibliometric and visual analysis. Front Cardiovasc Med 2024;11:1323918.
13. Yeung AW. A revisit to the specification of sub-datasets and corresponding coverage timespans when using Web of Science Core Collection. Heliyon 2023;9:e21527.
14. Chen C. CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature. J Am Soc Inform Sci Technol 2006;57:359-77.
15. Lavie CJ, Arena R, Swift DL, Johannsen NM, Sui X, Lee DC, et al. Exercise and the cardiovascular system: Clinical science and cardiovascular outcomes. Circ Res 2015;117:207-19.
16. Lavie CJ, Laukkanen JA, Nath KA. Cardiorespiratory fitness and mayo clinic proceedings. Mayo Clin Proc 2025;100:402-4.
17. Dibben G, Faulkner J, Oldridge N, Rees K, Thompson DR, Zwisler AD, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev 2021;11:CD001800.
18. Grace SL, Taylor RS, Gaalema DE, Redfern J, Kotseva K, Ghisi G. Cardiac rehabilitation: A global perspective on where we have come and where we must go. JACC Adv 2023;2:100412.
19. Redfern J, Gallagher R, O’Neil A, Grace SL, Bauman A, Jennings G, et al. Historical context of cardiac rehabilitation: Learning from the past to move to the future. Front Cardiovasc Med 2022;9:842567.
20. Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, et al. Exercise-based rehabilitation for patients with coronary heart disease: Systematic review and meta-analysis of randomized controlled trials. Am J Med 2004;116:682-92.
21. Heran BS, Chen JM, Ebrahim S, Moxham T, Oldridge N, Rees K, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev 2011;7:CD001800.
22. Leon AS, Franklin BA, Costa F, Balady GJ, Berra KA, Stewart KJ, et al. Cardiac rehabilitation and secondary prevention of coronary heart disease: An American Heart Association scientific statement from the council on clinical cardiology (subcommittee on exercise, cardiac rehabilitation, and prevention) and the council on nutrition, physical activity, and metabolism (subcommittee on physical activity), in collaboration with the American association of Cardiovascular and Pulmonary Rehabilitation. Circulation 2005;111:369-76.
23. Clark AM, Hartling L, Vandermeer B, McAlister FA. Meta-analysis: Secondary prevention programs for patients with coronary artery disease. Ann Intern Med 2005;143:659-72.
24. Suaya JA, Shepard DS, Normand SL, Ades PA, Prottas J, Stason WB. Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery. Circulation 2007;116:1653-62.

 

How to Cite this article: Chen N | Visualization Analysis of Research  Progress and Trends in Coronary Heart Disease Cardiac Rehabilitation Based on Bibliometrics | Journal of Regenerative Science | Jun-Jun 2026; 6(1): 14-21.

 

[Article Text HTML]       [Full Text PDF] 

Visual Analysis of Research Progress and Trends in Extracorporeal Shock Wave Therapy for Coronary Heart Disease

/0 Comments/in /by

Original Article | Vol 5 | Issue 2 |  July-December 2025 | page: 20-27 | Na Chen

DOI: https://doi.org/10.13107/jrs.2025.v05.i02.175

Open Access License: CC BY-NC 4.0

Copyright Statement: Copyright © 2025; The Author(s).

Submitted Date: 25 Oct 2025, Review Date: 12 Nov 2025, Accepted Date: Nov 2025 & Published: 30 Dec 2025

Author: Na Chen [1]

[1] Department of Internal Medicine, Peking University Hospital, Beijing, China

Address of Correspondence
Na Chen,
Department of Internal Medicine, Peking University Hospital, Beijing, China. E-mail: 18901267905@163.com; CN09558@pku.edu.cn.

Abstract

Purpose: Extracorporeal shock wave therapy (ESWT) has emerged as a promising non-invasive intervention in cardiovascular disease (CVD) management, with increasing research interest over the past two decades. This study aimed to systematically analyze the research progress, hotspots, and development trends in ESWT for CVD using bibliometric methods, providing a comprehensive overview for subsequent research.
Methods: Literature related to ESWT and CVD was retrieved from the Web of Science Core Collection database, covering the period from 1999 to August 2025. The search strategy was defined as TS=([Shock wave OR Extracorporeal shock wave therapy OR ESWT] AND [Cardiovascular disease OR Coronary artery disease OR Myocardial ischemia OR Heart failure]). After excluding non-English studies, proceeding papers, retracted publications, and early access articles, 465 valid articles were included. Bibliometric analysis was performed using VOSviewer and CiteSpace software, focusing on publication trends, country/institution contributions, author collaborations, journal distributions, keyword co-occurrence, and cited references.
Results: A total of 465 publications involving 3019 authors from 1001 institutions across 55 countries were included, with 15,556 citations from 3104 sources. The annual number of publications has shown a steady growth trend since 2017. The United States (133 documents, 53.3 average citations) was the most influential country, followed by China (82 documents) and Germany (47 documents). Tohoku University (20 documents, 56.1 average citations) and Mayo Clinic (11 documents, 79.7 average citations) were leading institutions. Hiroaki Shimokawa and Hon-Kan Yip (18 documents each) were the most productive authors. Heart Rhythm (15 documents, 44.8 average citations) and Circulation (9 documents, 140.2 average citations) were core journals in this field. High-frequency keywords included “heart failure” (56 times), “coronary artery disease” (44 times), and “mortality” (41 times), with “outcome” being recent burst terms (2023–2025). The top-cited reference was a 2004 study on ESWT improving ischemia-induced myocardial dysfunction in pigs (87 citations).
Conclusion: ESWT for CVD is a rapidly developing research field, with the United States leading in academic influence. Current research focuses on myocardial ischemia, heart failure, and therapeutic efficacy/safety, while future trends may involve exploring mechanisms related to extracorporeal shock wave action and expanding clinical applications in comorbidities.
Keywords: Extracorporeal shock wave therapy, Cardiovascular disease, Bibliometrics, CiteSpace, VOSviewer

References:

1. GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018;392:1736-88.
2. Spadaccio C, Benedetto U. Coronary artery bypass grafting (CABG) vs. percutaneous coronary intervention (PCI) in the treatment of multivessel coronary disease: Quo vadis? -A review of the evidences on coronary artery disease. Ann Cardiothorac Surg 2018;7:506-15.
3. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016;37:2129-200.
4. Chen N, Ji H. Cardiac shock wave therapy in cardiovascular diseases. J Regen Sci 2023;3:81-6.
5. Simplicio CL, Purita J, Murrell W, Santos GS, Dos Santos RG, Lana JF. Extracorporeal shock wave therapy mechanisms in musculoskeletal regenerative medicine. J Clin Orthop Trauma 2020;11:S309-18.
6. Kobayashi R, Camargo LS, Moya D. Latin American survey on shock wave therapy. J Regen Sci 2024;4:8-11.
7. Simplício CL, Rodrigues IJ, De Barros GA. Extracorporeal shock waves in metabolic inflammation. J Regen Sci 2024;4:18-25.
8. Kou D, Chen Q, Wang Y, Xu G, Lei M, Tang X, et al. The application of extracorporeal shock wave therapy on stem cells therapy to treat various diseases. Stem Cell Res Ther 2024;15:271.
9. Wang M, Yang D, Hu Z, Shi Y, Ma Y, Cao X, et al. Extracorporeal cardiac shock waves therapy improves the function of endothelial progenitor cells after hypoxia injury via activating PI3K/Akt/eNOS signal pathway. Front Cardiovasc Med 2021;8:747497.
10. Nishida T, Shimokawa H, Oi K, Tatewaki H, Uwatoku T, Abe K, et al. Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo. Circulation 2004;110:3055-61.
11. Fukumoto Y, Ito A, Uwatoku T, Matoba T, Kishi T, Tanaka H, et al. Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease. Coron Artery Dis 2006;17:63-70.
12. Jia N, Zhang R, Liu B, Liu B, Qi X, Lan M, et al. Efficacy and safety of cardiac shock wave therapy for patients with severe coronary artery disease: A randomized, double-blind control study. J Nucl Cardiol 2022;29:2404-19.
13. Li X, Zhang C, Liu C, Ma Y, Shi Y, Ye Y, et al. Principle and design of clinical efficacy observation of extracorporeal cardiac shock wave therapy for patients with myocardial ischemia-reperfusion injury: A prospective randomized controlled trial protocol. PLoS One 2023;18:e0294060.
14. Holfeld J, Nägele F, Pölzl L, Engler C, Graber M, Hirsch J, et al. Cardiac shockwave therapy in addition to coronary bypass surgery improves myocardial function in ischaemic heart failure: The CAST-HF trial. Eur Heart J 2024;45:2634-43.
15. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 2010;84:523-38.
16. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ 2021;372:n71.
17. Zhang J, Zhang J, Jin J, Jiang X, Yang L, Fan S, et al. Artificial intelligence applied in cardiovascular disease: A bibliometric and visual analysis. Front Cardiovasc Med 2024;11:1323918.
18. Yeung AW. A revisit to the specification of sub-datasets and corresponding coverage timespans when using Web of Science Core Collection. Heliyon 2023;9:e21527.
19. Chen C. CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature. J Am Soc Inform Sci Technol 2006;57:359-77.
20. Ito K, Fukumoto Y, Shimokawa H. Extracorporeal shock wave therapy for ischemic cardiovascular disorders. Am J Cardiovasc Drugs 2011;11:295-302.
21. Sung PH, Fu M, Chiang HJ, Huang CR, Chu CH, Lee MS, et al. Reduced effects of cardiac extracorporeal shock wave therapy on angiogenesis and myocardial function recovery in patients with end-stage coronary artery and renal diseases. Biomed J 2021;44:S201-9.
22. Uwatoku T, Ito K, Abe K, Oi K, Hizume T, Sunagawa K, et al. Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs. Coron Artery Dis 2007;18:397-404.
23. Kikuchi Y, Ito K, Ito Y, Shiroto T, Tsuburaya R, Aizawa K, et al. Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris. Circ J 2010;74:589-91.
24. Aicher A, Heeschen C, Sasaki K, Urbich C, Zeiher AM, Dimmeler S. Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: A new modality to increase efficacy of cell therapy in chronic hind limb ischemia. Circulation 2006;114:2823-30.

How to Cite this article: Chen N . Visual analysis of research progress and trends in extracorporeal shock wave therapy for coronary heart disease. Journal of Regenerative Science. July-Decemnber 2025;5(2):20-27

 

[Article Text HTML]       [Full Text PDF]