Posts

Personalized Multimodal Treatment for Adhesive Capsulitis: A Case Series on Regenerative Medicine and Noninvasive Therapies

Original Article | Vol 4 | Issue 2 |  July-December 2024 | page: 12-14 | Napoliane Costa Santos, André Vinicius Saueressig Kruel, Alex Pontes de Macedo, Fabio Ramos Costa, Luyddy Pires, Maria Laura Schiefelbein, Palmerindo Antônio Tavares de Mendonça Néto, Renata Takeyama de Oliveira, Daiane Agostini, Jose Fábio Lana

DOI: https://doi.org/10.13107/jrs.2024.v04.i02.145


Author: Napoliane Costa Santos [1], André Vinicius Saueressig Kruel [2], Alex Pontes de Macedo [1], Fabio Ramos Costa [3], Luyddy Pires [1], Maria Laura Schiefelbein [4], Palmerindo Antônio Tavares de Mendonça Néto [5], Renata Takeyama de Oliveira [1], Daiane Agostini [2], Jose Fábio Lana [1]

[1] Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil,
[2] Proregen Clínica Médica, Bento Gonçalves, Rio Grande do Sul, Brasil.
[3] TRATE – Traumatologia Esportiva, Salvador, Brazil,
[4] Departamento de Ortopedia, TRATE, Traumatologia Esportiva, Salvador, BA, Brazil, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil,
[5] Instituto Regenera Dor, Juazeiro do Norte, Ceará, Brazil.

Address of Correspondence
Dr. André Kruel
Proregen Clínica Médica, Bento Gonçalves, Rio Grande do Sul, Brasil.
E-mail: kruel.andre@gmail.com


Abstract

Introduction: Adhesive capsulitis causes chronic shoulder pain and restricted range of motion (ROM). Conventional treatments often offer limited relief, prompting the need for innovative approaches, such as high-intensity pulsed electromagnetic field (PEMF) therapy, shockwave therapy, and orthobiologic injections.

Objective: To evaluate the efficacy of a multimodal approach combining shockwave therapy, high-intensity PEMF therapy, orthobiologic injections, and complementary therapies in improving pain and shoulder function in patients with adhesive capsulitis.

Methods: This retrospective case series included five patients treated in Indaiatuba, São Paulo, Brazil, between May 2023 and October 2024. Individualized multimodal protocols were performed. Pain and ROM were assessed pre- and post-treatment.

Discussion: All patients showed significant improvements in pain and ROM after treatment. High-intensity PEMF therapy, shockwave therapy, and orthobiologics enhanced tissue regeneration, supported by complementary therapies. Personalized protocols optimized outcomes, with synergistic effects observed between treatments.

Conclusion: A multimodal, personalized approach effectively reduced pain and improved function in adhesive capsulitis patients. This strategy shows promise, especially for those unresponsive to conventional treatments, warranting further research.

Keywords: Adhesive capsulitis, High intensity pulsed electromagnetic field therapy, Orthobiologics, Regenerative medicine, Shockwave therapy


References:

  1. Mello DP, Corbin JN, Holanda LS, Pascarelli L, Nishimura EM, Almeida TB. Incidence and epidemiology of adhesive capsulitis during the COVID-19 pandemic. Acta Ortop Bras 2023;31:e261132.
  2. Varriano G, Nardone V, Brunese MC, Bruno M, Santone A, Brunese L, Zappia M. An approach leveraging radiomics and model checking for the automatic early diagnosis of adhesive capsulitis. Dent Sci Rep 2024;14:18878.
  3. Omar FK, Alshaimaa ME, Khaled SA. Adhesive capsulitis of the shoulder joint: Correlation between the utrasonographic and MRI findings. Ain Shams Med J 2024;75:387-98.
  4. Riccardo P, Federico P, Federico Z, Giovanni M, Maribel MP, Alberto T, et al. Adhesive capsulitis of the shoulder: Current concepts on the diagnostic work-up and evidence-based protocol for radiological evaluation. Diagnostics (Basel) 2023;13:3410.
  5. Evin C. Effectiveness of strengthening and stretching exercise along with proprioceptive neuromuscular facilitation techniques to reduce pain and improve shoulder range of motion in adhesive capsulitis: A literature review. Physiotherapy 2024;18:81-9.
  6. De la Corte-Rodríguez H, Román-Belmonte JM, Rodríguez-Damiani BA, Vázquez-Sasot A, Rodríguez-Merchán EC. Extracorporeal shock wave therapy for the treatment of musculoskeletal pain: A narrative review. Healthcare (Basel) 2023;11:2830.
  7. Mayer Y, Shibli JA, Saada HA, Melo M, Gabay E, Barak S, et al. Pulsed electromagnetic therapy: Literature review and current Brazilian Dent J 2024;35:e24-6109.
  8. Mittermayr R, Haffner N, Feichtinger X, Schaden W. The role of shockwaves in the enhancement of bone repair-from basic principles to clinical Injury 2021;52 Suppl 2:S84-90.
  9. Bakaliuk TG, Gordiychuk I, Stelmakh HO, Makarchuk NR, Stoliarchuk VM. Application of shock wave therapy in neurorehabilitation (literature review). Art Med 2022;1:138.
  10. Blanchard E, Harvi J, Vasudevan J, Swanson RL. Platelet-rich plasma for adhesive capsulitis: A systematic review. Cureus 2023;15:e46580.
  11. Thu AC, Kwak SG, Shein WN, Htun M, Htwe TT, Chang M Comparison of ultrasound-guided platelet-rich plasma injection and conventional physical therapy for management of adhesive capsulitis: A randomized trial. J Int Med Res 2020;48:300060520976032.
  12. Sampson S, Bemden AB, Aufiero D. Autologous bone marrow concentrate: Review and application of a novel intra-articular orthobiologic for cartilage Phys Sportsmed 2013;41:7-18.
  13. Katz NB, Tsitsilianos N, Nowak AS, Douglas SR, Tenforde AS, Borg-Stein J. Advanced non-operative interventions for anterior knee pain. Curr Rev Musculoskeletal Med 2024;17:589-615.
  14. Oliveira VO, Vergara JM, Oliveira VF, Lara PH, Nogueira LC, Arliani GG. Extracorporeal shockwave therapy in shoulder injuries: Prospective study. Acta Ortop Bras 2021;29:268-73.
  15. Tedla JS, Sangadala Proprioceptive neuromuscular facilitation techniques in adhesive capsulitis: A systematic review and meta-analysis. J Musculoskelet Neuronal Interact 2019;19:482-91.
  16. De la Barra Ortiz HA, Parizotto N, Arias M, Liebano R. Effectiveness of high-intensity laser therapy in the treatment of patients with frozen shoulder: A systematic review and meta-analysis. Lasers Med Sci 2023;38:266.
  17. Xue X, Song Q, Yang X, Kuati A, Fu H, Liu Y, et al. Effect of extracorporeal shockwave therapy for rotator cuff tendinopathy: A systematic review and meta-analysis. BMC Musculoskeletal Disord 2024;25:357.

How to Cite this article: Santos NC, Saueressig Kruel AV, de Macedo AP, Costa FR, Pires L, Schiefelbein ML, de Mendonça Néto PAT, de Oliveira RT, Agostini D, Fábio Lana J | Personalized Multimodal Treatment for Adhesive Capsulitis: A Case Series on Regenerative Medicine and Noninvasive Therapies. | Journal of Regenerative Science | July-December 2024; 4(2): 12-17.

 

 


[Article Text HTML]       [Full Text PDF]