Review Article | Volume 1 | Issue 1 | JRS December 2021 | Page 44-47 | Eduard Alentorn-Geli, Patricia Laiz, Alfred Ferré-Aniorte, Roberto Seijas, David
Barastegui, Pedro Álvarez-Díaz, Xavier Cuscó, Cristina Sánchez, Luís García, Montse García-Balletbó, Ramón Cugat. DOI: 10.13107/jrs.2021.v01.i01.023
Author: Eduard Alentorn-Geli [1,2,3], Patricia Laiz [1,2], Alfred Ferré-Aniorte [1,2], Roberto Seijas [1,2], David Barastegui [1,2,3], Pedro Álvarez-Díaz [1,2,3], Xavier Cuscó [1,2], Cristina Sánchez [1,2], Luís García [1,2], Montse García-Balletbó [1,2], Ramón Cugat [1,2,3]
[1] Instituto Cugat, Hospital Quironsalud. Plaza Alfonso Comín 5-7, Planta -1, 08027 Barcelona, Spain.
[2] Fundación García Cugat, Plaza Alfonso Comín 5-7, Planta -1, 08027 Barcelona, Spain. Barcelona, Spain.
[3] Mutualidad de Futbolistas (Real Federación Española de Fútbol), Delegación catalana. Ronda Sant Pere 19-21, Entresuelo, 08010, Barcelona, Spain.
Address of Correspondence
Dr. Ramón Cugat Bertomeu, MD, PhD,
Instituto Cugat, Plaza Alfonso Comín 5-7, 08023 Barcelona, Spain.
E-mail: ramon.cugat@sportrauma.com
Abstract
Multilineage-differentiating stress-enduring (MUSE) cells are non-tumorigenic pluripotent stem cells with endogenous reparative properties. These cells have a very powerful ability to adapt to global environment changes and are thus stress-tolerant cells. Interestingly, MUSE cells can differentiate into cells representative of all three germ layers. There has been a number of studies demonstrating its powerful regenerative power in several disorders: type-1 diabetes mellitus, myocardial infarction, stroke, glomerular-related kidney diseases, chronic liver failure, and ischemia-reperfusion lung injury. Recent data have also suggested that MUSE cells have significant repair properties for osteochondral lesions. The present article will review what are MUSE cells and how they work, the application of these cells into different disorders, and the studies up-to-date regarding MUSE cells in orthobiologic.
Keywords: Muse cells, stem cells, regenerative, regeneration.
References:
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| How to Cite this article: Geli EA, Laiz P, Aniorte AF, Seijas R, Barastegui D, Díaz PÁ, Cuscó X, Sánchez C, García L, Balletbó MG, Ramón Cugat R | Multilineage-differentiating Stress-enduring (MUSE) Cells in Orthobiologics: Are they the Future? | Journal of Regenerative Science | Dec 2021; 1(1): 44-47. |
